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A possible association between cervical erosion in pregnant women and congenital abnormalities in their children-a population-based case-control study

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DOI: 10.4236/health.2010.28140    3,632 Downloads   7,480 Views   Citations

ABSTRACT

Objective to study the possible association between erosion of cervix in pregnant women (ECP) and structural birth defects, i.e. congenital abnormalities (CA) in their offspring. Study design: Comparison of cases with CA and all matched controls without any CA born to wo- men with prospectively and medical record ECP in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA). Results: HCC- SCA contained 22,843 cases and 38,151 matched controls, the informative offspring of 40 (0.18%) case mothers and the newborns of 25 control mothers (0.07%) with ECP were compared and the higher risk for total CA (adjusted OR with 95% CI: 2.7, 1.6-4.4) was found explained by the higher risk of 9 cases with hypospadias (OR with 95% CI: 4.5, 2.1-9.7) and 10 cases with car-diovascular CAs (OR with 95% CI: 3.4, 1.6-7.1), particularly with conotruncal CAs. Conclusions: An unexpected possible association of ECP with higher risk for hypospadias and conotrun-cal cardiovascular CAs was found and these findings are considered as signals that need confirmation or rejection

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Bánhidy, F. , Ács, N. , Puhó, E. and Czeizel, A. (2010) A possible association between cervical erosion in pregnant women and congenital abnormalities in their children-a population-based case-control study. Health, 2, 945-950. doi: 10.4236/health.2010.28140.

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