Share This Article:

Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against Helignosomoides bakeri

Abstract Full-Text HTML XML Download Download as PDF (Size:33KB) PP. 890-892
DOI: 10.4236/health.2012.410135    3,471 Downloads   4,960 Views   Citations

ABSTRACT

To test effect of a synthetic Aluminium-Magnesium Silicate (AMS) on anthelmintic efficacy of piperazine citrate (PC), 35 mice were infected by dosing each, 0.15 ml Helignosomoides bakeri sample which contained 200 infective larvae, per os. Following comfirmation of establishment of infection by faecal floatation, they were assigned into seven groups of 5 each, and were treated with piperazine citrate, per os, at rates of 110 mg/kg (PC), 110 mg/kg (PC in AMS), 82.5 mg/kg (PC), 82.5 mg/kg (PC in AMS), 55 mg/kg (PC) and 55 mg/kg (PC in AMS) respectively. The seventh group served as untreated control. Mean Eggs Per Gramm of faeces (EPG) were 375 ± 32.27, 175 ± 14.43, 830 ± 1.04, 70 ± 12.25, 850 ± 293.06, 370 ± 58.54 and 2,200 ± 2.55 respectively. This showed EPG reduction rates of 83%, 92%, 62%, 97%, 61% and 83% among the respective treated groups.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Ezeibe, M. , Dire, C. , Anosa, G. , Chikelu, O. , Okoroafor, O. , Okorie, O. , Ngene, A. , Idika, I. , Ogunniran, T. and Ezeala, I. (2012) Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against Helignosomoides bakeri. Health, 4, 890-892. doi: 10.4236/health.2012.410135.

References

[1] Waller, P.J., Echevarria, F., Eddi, C., Maciel, S., Nari, A. and Hansen, J.W. (1996) The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: General overview. Veterinary Parasitology, 62, 181-187. doi:10.1016/0304-4017(95)00909-4
[2] Tarigo-Martinie, J.L., Wyatt, A.R. and Kaplan, R.M. (2001) Prevalence and clinical implications of anthelmintic resistance in cyathostomes of horses. Journal of the American Veterinary Medical Association, 218, 1957-1960. doi:10.2460/javma.2001.218.1957
[3] Kaplan, R.M. (2002) Anthelmintic resistance in nematods of horses. Veterinary Research, 33, 491-507. doi:10.1051/vetres:2002035
[4] Githiori, J.B., Hoglund, J., Wsaller, P.J. and Baker, R.L. (2003) The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites, Haemonchus contortus of sheep and Helignosomoides polygyrus of mice. Veterinary Parasitology, 116, 23-34. doi:10.1016/S0304-4017(03)00218-8
[5] Vanderbilt, T.I. (1992) Veegum the versatile ingredient for pharmaceutical formulation. RT Vanderbilt Co., Inc. Technical Literature, Veegum.
[6] Ramachandran,V.G. (2001) Multani mitti or fuller earth, uses of multani mitti in India. www.fromnaturewithlove.com/soap/product.
[7] Foster, E. and Smith, K. (2007) Aluminium-Magnesium Silicate is used as antacid, antiulcer and in control of diarrhea. Journal of Renal Nutrition, 4, 50-53.
[8] Schils, S. (2002) The use of clay in the fight against harmful effect of ammonia. Journal of Renal Nutrition, 4, 32-36.
[9] Elmore, A.R. (2003) Cosmetics ingredients review panel’s report. International Journal of Toxicology, 22, 37-102.
[10] Brent,W., Gunderson, G.H., Khalid, H.I. and John, C.R. (2001) What do we realy know about antibiotics pharmacotherapy? Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 21, 302S-318S.
[11] Ezeibe, M.C.O. (2006) Admacine. Federal Republic of Nigeria. Patents and Design Act. Cap. 344. LDN. 1990. No. 16448.
[12] Ezeibe, M.C.O., Okafor, U.C., Okoroafor, O.N., Eze, J.I., Ngene, A.A., Animoke, P.C. and Mbuko, I.J. (2011) Effect of Aluminium-Magnesium Silicate on anticcocidial activity of sulphadimidin. Tropical Veterinarian, 29, 41-44.
[13] Ezeibe, M.C.O., Elendu-Eleke, N.P., Okoroafor, O.N. and Ngene, A.A. (2012) Adjuvant effect of a synthetic Aluminium-Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei. Health, 4, 448-451.
[14] Ezeibe, M.C.O., Anosa, G.N., Okorie, O.K., Elendu-Eleke, N.P., Okoroafor, O.N, Ngene, A.A. and Chikelu, O.N. (2012) Aluminium-Magnesium Silicate enhances antibacterial activity of Ampicillin trihydrate, against Salmonella gallinarum. Nature Precedings. http://precedings.nature.com/documents/6814/version/1/files/npre20126814-1.pdf

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.