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Molecular Particularity in Rare Tumour of Buttock: Case Report and Literature Review

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DOI: 10.4236/ojpathology.2012.24026    3,156 Downloads   4,912 Views  

ABSTRACT

Introduction: Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low-grade fibromyxoid sarcoma (LGFMS). Case Report: Reported herein is a case of primary tumour of buttock HSCT that had rare FUS-CREB3L1 fusion transcripts, a product of characteristic chromosomal abnormality t (7; 16) (q33; p11) of HSCT and LGFMS. The patient was a 48-year-old man who had a large solitary mass in the buttock. Histologically, it was composed of bland spindle cells with variable cellularity deposited in a densely hyalinized stroma alternating with myxoid areas. Characteristic collagen rosettes were scattered in the cellular areas. Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L1 fusion transcripts. In our knowledge is the second case may display a variant FUS/CREB3L1 fusion transcript in international literature. Conclusion: LGFMS and HSCT probably have a wider spectrum of morphologic features than previously thought, the awareness of which will help pathologists to avoid diagnostic pitfalls. Demonstration of the t (7; 16) translocation will help to diagnose difficult cases with unusual histologic features.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

E. Fatemi Hinde, F. Mishellany, P. Gimbergues and F. Penault-Llorca, "Molecular Particularity in Rare Tumour of Buttock: Case Report and Literature Review," Open Journal of Pathology, Vol. 2 No. 4, 2012, pp. 143-146. doi: 10.4236/ojpathology.2012.24026.

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