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Levels of Immunoglobulin Classes Are Not Associated with Severity of HIV Infection in Nigerian Patients

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DOI: 10.4236/wja.2012.23030    3,877 Downloads   6,126 Views   Citations

ABSTRACT

The serum concentrations of immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin M (IgM), total protein and albumin were measured in 35 Human Immunodeficiency Virus—positive, HAART (highly active antiretroviral therapy) na?ve subjects attending the PEPFAR (President's Emergency Plan for AIDS relief) clinic, University College Hospital, Ibadan and in 30 apparently healthy control subjects to assess the relationship between serum protein, immunoglobulin concentrations and laboratory indices of HIV disease (CD4 cell counts and viral load). Serum IgG (1008.6 ± 530.7 mg/dl), IgA (170.4 ± 69 mg/dl) and total protein (9.9 ± 1.7 g/dl) levels were higher among HIV positive subjects compared with mean values in healthy subjects (549.8 ± 193.8 mg/dl, 106.8 ± 26.4 mg/dl and 7.8 ± 0.5 g/dl respectively). The median serum IgM concentration (131mg/dl) was significantly higher in HIV positive subjects compared with 35 mg/dl in healthy controls (p < 0.001). Mean serum albumin concentration was significantly lower among HIV positive subjects (3.7 ± 0.7 g/dl), compared with 4.3 ± 0.3 g/dl in healthy subjects (p < 0.001). There were no significant differences observed in the levels of the immunoglobulin classes when HIV subjects with CD4 counts of <200 cell/μL were compared with subjects with CD4 counts > 200 cells/μL. There was also no statistically significant correlation observed between viral load and serum immunoglobulin levels.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

O. O. Akinpelu, Y. A. Aken'Ova and O. Ganiyu Arinola, "Levels of Immunoglobulin Classes Are Not Associated with Severity of HIV Infection in Nigerian Patients," World Journal of AIDS, Vol. 2 No. 3, 2012, pp. 232-236. doi: 10.4236/wja.2012.23030.

References

[1] B. Taiwo, “General HIV Medicine,” The Floating Gallery Press, 2004, pp. 3-30.
[2] A. Abayomi, N. Adomakoh and S. Adomakoh, “Respond?ng to the HIV Epidemic in the Developing World. Capacity Building and Technology Transfer for Monitoring with HAART; A Caribbean Experience,” African Journal of Medicine & Medical Sciences, Vol. 34, 2005, pp. 19-24.
[3] D. O. Olaleye, T. O. Harry and G. N. Odaibo, “The Virology and Dynamics of the Epidemic in Nigeria,” In: O. Adeyi, P. J. Kanki, O. Odutolu and J. A. Idoko, Eds., Aids in Nigeria: A Nation on the Threshold, Harvard Centre for Population and Development Studies, Cambridge 2006, pp. 37-66.
[4] J. M. Pascale, M. D. Isaacs, P. Contreras, B. Gomez, L. Lozano, E. Austin, M. C. De Martin, R. L. Gregory, McLaughlin and A. Amador, “Immunological Markers of Disease Progression in Patients Infected with the Human Imunodeficiency Virus,” Clinical and Vaccine Immunology, Vol. 4, No.4, 1997, pp. 474-477.
[5] O. G. Arinola, L. S. Salimonu, O. H. Okiwelu and C. P. Muller, “Levels of Immunoglobulin Classes, Acute Phase Proteins and Serum Electrophoresis in Nigerians Infected with Human Immmunodeficiency Virus,” European Journal of Scientific Research, Vol. 7, No. 3, 2005, pp. 34-44.
[6] O. G. Arinola and J. Igbi, “Serum Immunoglobulins and Circulating Immune Complexes in Nigerians with Human Immmunodeficiency Virus and Pulmonary Tuberculosis Infection,” Tropical Journal of Medical Research, Vol. 2, No. 2, 1998, pp. 41- 48.
[7] E. F. Lyamuya, M. I. Matee, M. Kasubi and F. Schentz, “Immunoglobulin Profile in HIV-1 Infected Children in Dares Salaam,” East African Medical Journal, Vol. 76, No. 7, 1999, pp. 370-375.
[8] E. F. Lyamuya, S. Y. Maselle and R. Matre, “Serum Immunoglobulin Profile in Asymptomatic HIV-1 Seropositive Adults and in Patients with AIDS in Dares Salaam Tanzania,” East African Medical Journal, Vol. 71, No. 1, 1994, pp. 24-28.
[9] L. Tavares, J. Botas, H. Feliciano, C. Carvalho, F. Antunes and J. D. Paiva, “Serum Immunoglobulin Profile in HIV Infection,” International AIDS Conference, Vol. 5, 4-9 June 1989, p. 436.
[10] E. S. Lugada, J. Mermin, B. Asjo, F. Kaharuza, R. Downing, N. Langeland, V. Ormaasen, J. Bruun, A. C. Awor and E. Ulvestad, “Immunoglobulin Levels Amongst Persons with and without HIV-1 Infection in Uganda and Norway,” Scandinavian Journal of Immunology, Vol. 59, 2004, pp. 203-208. doi:10.1111/j.0300-9475.2004.01376.x
[11] “Status of the Global Epidemic,” UNAIDS 2008 Report on the Global AIDS Epidemic, 2008, pp. 29-62.
[12] S. Moir, A. Malaspina, K. M. Ogwaro, E. T. Donoghue, C. W. Hallahan, L. A. Ehler, S. Liu, J. Adelsberger, R. Lapointe, P. Hwu, M. Baseler, J. M. Orenstein, T. W. Chun, J. A. Mican and A. S. Fauci, “HIV-1 Induces Phenotypic and Functional Perturbations of B Cells in Chronically in Fected Individuals,” Proceedings of the National Academy of Sciences of the USA, Vol. 98, No. 18, 2001, pp. 10362-10367. doi:10.1073/pnas.181347898
[13] P. Lundholm, “Immune and Autoimmune Responses to HIV-1 in Mucosa and Other Tissues,” Ph.D. Thesis, Karo-Linska Institute, Stockholm, 1999.
[14] B. A. I. Payne, D. A. Price, M. L. Schmid, E. Ong and M. H. Snow, “High Serum Protein and Gammaglobulins in Black Africans with HIV Infection—Is It Clinically Significant?” Journal of Infection, Vol. 54, No. 3, 2006, pp. e195-e196. doi:10.1016/j.jinf.2006.10.020
[15] S. H. Mehta, J. Astemborski, T. R. Sterling, D. L. Thomas and D. Vlahov, “Serum Albumin as a Prognostic Indicator for HIV Disease Progression,” AIDS Research and Human Retroviruses, Vol. 22, No. 1, 2006, pp. 14-21. doi:10.1089/aid.2006.22.14
[16] J. G. Feldman, S. J. Gange, P. Bacchetti, M. Cohen, M. Young, K. E. Squires, C. Williams, P. Goldwasser and K. Anastos, “Serum Albumin Is a Powerful Predictor of Survival among HIV-1 Infected Women,” Journal of Acquired Immune Deficiency Syndromes, Vol. 33, 2003, pp. 66-73. doi:10.1097/00126334-200305010-00010

  
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