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Greater Expansion of IFN-γ CD4+ NKT Cells in HIV-1 Compared with HIV-2-Infected Subjects with Preserved CD4+ T Cell Counts

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DOI: 10.4236/wja.2012.22014    2,572 Downloads   4,616 Views   Citations

ABSTRACT

Context: Human Natural Killer T cells are T lymphocytes that express an invariant αβ T cells receptors and NK cells receptors. They regulate innate and adaptive immune response but are susceptible to HIV-1 infection. Objective: We compare the frequency and the activity of NKT cells in HIV-1 and HIV-2 infected individuals with CD4+ counts greater than 500/mm3 using flow cytometry after overnight stimulation with phytohemagglutinin (PHA). Results: The frequency of NKT cells was similar between both groups and also to sero-negative control subjects. There were also no significant differences in the proportions of total NKT cells and the CD4+ NKT subset that secreted interferon gamma (IFN-γ) after polyclonal stimulation. However, there was a significantly higher frequency of IFN-γ CD4+ NKT cells in HIV-1-infected compared with HIV-2 infected subjects (p = 0.043). Conclusion: These data suggest there is no relationship between the functional activity of NKT cell subsets and the total NKT cell population in HIV infection. The expansion of IFN-γ CD4+ NKT cells in HIV-1 infection may serve as target for viral infection and may eventually result in their depletion during chronic infection.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

S. V. Nuvor, H. Whittle, S. Rowland-Jones and A. Jaye, "Greater Expansion of IFN-γ CD4+ NKT Cells in HIV-1 Compared with HIV-2-Infected Subjects with Preserved CD4+ T Cell Counts," World Journal of AIDS, Vol. 2 No. 2, 2012, pp. 103-108. doi: 10.4236/wja.2012.22014.

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