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Immune Activation in HIV-Infected Patients Treated with Different ARV Regimens

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DOI: 10.4236/wja.2012.22013    4,049 Downloads   6,474 Views  

ABSTRACT

Objectives: To evaluate the effects of starting therapy with either Truvada (TVD) or Combivir (CBV) in combination with Efavirenz (EFV) or a boosted Protease Inhibitor (LPV/r, ATV/r, fAPV/r and SQV/r) on clinical, immunological, and virological parameters in HIV-infected antiretroviral (ARV) naive patients. Methods: Twenty-seven patients were prospectively enrolled and received TVD-EFV, 32 TVD-PI/r, 24 CBV-EFV, and 23 CBV-PI/r. Immunovirological analyses were performed at baseline and after 3, 6, 9 and 12 months after initiation of therapy; a full set of data is available for 51 patients. Results: Median CD4+ cell counts and HIV-RNA plasma viremia were comparable in the four groups of patients (TVD-EFV, TVD-PI/r, CBV-EFV, CBV-PI/r) at baseline. At month 12 HIV RNA plasma viremia was <50 cps/ml in all patients. Median CD4 cell counts increases were higher, although not significantly, in CBV-EFV and TVD-EFV patients. Finally, CD8+/CD38+/CDRO+T lymphocytes were significantly decreased after 12 months of therapy in all patients with, possibly, a faster effect seen in the EFV groups. Conclusions: Immunologic parameters are similarly affected by different ARV combinations, even if EFV-associated immunomodulation might be marginally better.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

A. Uglietti, S. Lo Caputo, M. Lauriola, M. De Gennaro, E. Chiesa, M. Coen, R. Terzi, D. H. Bray, R. Maserati, D. Trabattoni and M. Clerici, "Immune Activation in HIV-Infected Patients Treated with Different ARV Regimens," World Journal of AIDS, Vol. 2 No. 2, 2012, pp. 97-102. doi: 10.4236/wja.2012.22013.

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