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Red cell distribution width in patients with HIV infection

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DOI: 10.4236/ojim.2012.21002    3,954 Downloads   7,492 Views   Citations

ABSTRACT

Objective: To examine the association between elevated levels of red cell distribution width (RDW) and cardiovascular risk factors (CVRF) and metabolic syndrome (MS) in HIV-patients. Methods: Cross-sectional study including all asymptomatic HIV-outpatients under follow-up during 2007. Patients completed a questionnaire about CVRF, underwent a physical examination, and an 8-hour fasting blood analysis. Elevated RDW was defined as ≥75th percentile. Patients with and without an elevated RDW were compared. Results: 666 patients (79.3% men) were included: mean age 44.7 years, mean CD4 506/mm3 and 87.5% on antiretroviral therapy (85.3% with undetectable viral load). Mean RDW was 13.7% (range: 7.7% - 33.6%; 75th percentile, 14.1%). The prevalence per quartile of MS was 15.7%, 9.3%, 18.8% and 16.6% and of patients with CVRF > 20% was 8.4%, 4.0%, 4.4%, and 6.4%, respectively (p > 0.05); 23.4% of the patients had an elevated RDW (>14.1%). The top percentile of RDW was associated with AIDS (OR 1.6; 95% CI, 1.0 - 2.4; p = 0.02), detectable viral load (OR 1.5; 95% CI, 1.01 - 2.4; p = 0.04) and hypertension (OR 2.3; 95% CI, 1.4 - 4.0; p = 0.001). Conclusions: In HIV-outpatients, higher RDW is related with detectable viral load and with AIDS. Although it was associated with hypertension, we found no relation with MS nor with higher cardiovascular risk.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Gallego, M. , Pérez-Hernández, I. , Palacios, R. , Ruiz-Morales, J. , Nuño, E. , Márquez, M. and Santos, J. (2012) Red cell distribution width in patients with HIV infection. Open Journal of Internal Medicine, 2, 7-10. doi: 10.4236/ojim.2012.21002.

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