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Synthesis and in vitro antibacterial evaluation of some thiosemicarbazides and thiosemicarbazones

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DOI: 10.4236/jbise.2012.52006    3,401 Downloads   7,023 Views   Citations

ABSTRACT

In the present study various thiosemicarbazides and thiosemicarbazones were synthesized and screened for their antimicrobial activity. Among the ligands tested, compounds 1, 3, 4 and 5 demonstrated inhibitory effects at 0.4 - 0.5 μM concentrations against E. coli while 1-(4-fluorobenzoyl)-N4-ethyl-thiosemicar-bazide (3) demonstrated the maximum inhibitory effective compound against E. coli, also possessing high water solubility. Instead, compound 3 demonstrated weak antibiotic effects against S. aurous while compounds 4 - 6 demonstrated significant antibacterial effects at 0.4 - 0.42 μM against the latter organism. Chloramphenicol was used as the positive control.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Sheikhy, M. , Jalilian, A. , Novinrooz, A. and Motamedi-Sedeh, F. (2012) Synthesis and in vitro antibacterial evaluation of some thiosemicarbazides and thiosemicarbazones. Journal of Biomedical Science and Engineering, 5, 39-42. doi: 10.4236/jbise.2012.52006.

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