Low Molecular Weight Poly(Lactide-co-Caprolactone) for Tissue Adhesion and Tetracycline Hydrochloride Controlled Release in Wound Management

Sumana Sriputtirat, Wasinee Boonkong, Somchai Pengprecha, Amorn Petsom, Nuttha Thongchul

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DOI: 10.4236/aces.2012.21003                

Abstract

The use of biopolymers as bioadhesives for human tissue is becoming a preferred alternative to suturing due to their superior adhesive, biocompatible, and biodegradable properties. In this work, low molecular weight poly(L-lactide-co-ε-caprolactone) (P(LA-co-CL) was synthesized to achieve the glass transition temperature (T_g) of the copolymer at ambient temperature so that during application on the skin, the copolymer when combined with chitosan (CHI) into the CHI/P(LA-co-CL) film could provide the strong support at the injury site. Using alcohols with different numbers of hydroxyl groups as the co-initiator in polymerization provided the distinctive characteristics of copolymers. Among all copolymers synthesized, P(LA-co-CL) copolymer using pentaerythritol as the co-initiator when combined with CHI at the ratio of copolymer/CHI at 70/30 yielded the good film properties in tissue adhesion and tetracycline hydrochloride release.

Keywords

L-Lactide; ε-Caprolactone; Chitosan; Tissue Adhesive; Tetracycline Hydrochloride Release; Co-Initiator; Wound Healing

Conflicts of Interest

The authors declare no conflicts of interest.

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