Arterial mechanical properties after replacement or reconstruction of the aortic root

Kai Mortensen, Muhammet Aydin, Alexander M. J. Bernhardt, Verena Appenzeller, Peter N. Robinson, Jürgen Berger, Herman Reichenspurner, Yskert von Kodolitsch

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DOI: 10.4236/wjcd.2012.21002                

Abstract

Background: Alteration of arterial mechanical properties has adverse effects on cardiovascular disease in Marfan syndrome. Design: We compared central pulse pressure, augmentation index adjusted to a heart rate of 75 beats per minute (AIx@HR75) and pulse wave velocity in 25 Marfan patients who had under-gone an aortic valve-sparing reimplantation operation, in 15 Marfan patients after composite valve grafting operation, and in 40 age and sex-matched Mar-fan patients who had not undergone surgery. Results: Central pulse pressure, AIx@HR75 and pulse wave velocity were similar across all three patient groups. Exclusively AIx@HR75 was higher with conduit operations than in persons without any surgery (P = 0.03). Multivariate linear regression analysis documented association of AIx@HR75 with body height (P < 0.001) and with a history of aortic valve-sparing reimplantation operation (P < 0.001) or with a composite valve grafting operation (P = 0.006). Conclusions: Arterial mechanical properties are only mildly altered by surgery of the aortic root without difference between the reimplantation and conduit operation.

Keywords

Arterial Stiffness; Aortic Valve-Sparing Reimplantation Operation; Composite Valve Grafting Operation; Marfan Syndrome

Conflicts of Interest

The authors declare no conflicts of interest.

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