Author(s)

Luiz Felipe Schmitz de Souza¹, Tiago Tizziani^2*, Larissa Sens¹, Dalila Venzke¹, Inês Maria Costa Brighente², Moacir Geraldo Pizzolatti², Ricardo José Nunes¹

¹Laboratório Estrutura e Atividade, Departamento de Química, LEAT-CFM-UFSC, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, Brazil.
²Laboratório de Química de Produtos Naturais, Departamento de Química, LQPN-CFM-UFSC, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, Brazil.

This work describes the synthesis of seven new sulfonyl hydrazones, which were proposed from the general structure of acyl hydrazones and 2,4-dinitrosulfonamides. Sulfonyl hydrazones are a class of compounds known to exhibit a wide range of biological activity. In this sense, the study of the pharmacokinetic properties of the bioactive molecules is of extreme importance; therefore, in this article the permeability of these compounds with in vitro PAMPA assay mimetizing the permeability through the gastrointestinal tract as well as lipophilicity through miLogP was investigated. All compounds presented good permeability results; it was possible to make a structure-activity relationship with the obtained results and a comparison between the results.

Sulfonyl Hydrazones, PAMPA Permeability, Organic Synthesis, Medicinal Chemistry

Souza, L. , Tizziani, T. , Sens, L. , Venzke, D. , Brighente, I. , Pizzolatti, M. and Nunes, R. (2019) Synthesis and PAMPA Permeability Assay of New Sulfonyl Hydrazone Derivatives. Journal of Biosciences and Medicines, 7, 111-120. doi: 10.4236/jbm.2019.79010.