Prof. Long-Sheng Chang

The Ohio State University College of Medicine, USA

Professor

Email: Long-Sheng.Chang@nationwidechildrens.org

Qualifications

1985 Postdoctoral Training, Princeton University

1984 Ph.D., Rutgers University (Formerly UMDNJ)

1978 B.Sc., National Taiwan University

Publications (Selected)

1. Chow, H.Y., Dong, B., Duron, S.G., Campbell, D.A., Ong, C.C., Hoeflich, K.P., Chang, L.-S., Welling, D.B., Yang, Z., Chernoff, J. 2015. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget 6:1981-1994. PMID: 25596744
2. Petrilli, A., Copik, A., Posadas, M., Chang, L.-S., Welling, D.B., Giovannini, M., Fernandez-Valle, C. 2014. LIM domain kinases as a therapeutic target for neurofibromatosis type 2. Oncogene 33:3571-3582. PMID: 23934191
3. Spear, S.A., S.S. Burns, J.L. Oblinger, Y. Ren, L. Pan, A.D. Kinghorn, D.B. Welling, L.-S. Chang. 2013. Natural compounds as potential treatments of NF2-deficient schwannoma and meningioma: cucurbitacin D and goyazensolide. Otol. Neurotol. 34:1519-1527. PMID: 23928514
4. Burns, S.S., E.A. Akhmametyeva, J.L. Oblinger, M.L. Bush, J. Huang, V. Senner, C.-S. Chen, A. Jacob, D.B. Welling, L.-S. Chang. 2013. AR-42, a histone deacetylase inhibitor, differentially affects cell-cycle progression of meningeal and meningioma cells and potently inhibits NF2‒ meningioma growth. Cancer Res. 73:792-803. PMID: 23151902
5. Wang, Y., E. Kim, X. Wang, B.G. Novitch, K. Yoshikawa, L.-S. Chang, Y. Zhu. 2012. Neonatal MEK/ERK pathway inhibition rescues fate-specification defects of neural progenitors and structural brain abnormalities caused by Nf1 deficiency. Cell 150:816-830. PMID: 22901811
6. Jacob, A., Oblinger, J., Bush, M.L., Brendel, V., Santarelli, G., Chaudhury, A.R., Kulp, S., La Perle, K.M., Chen, C.-S., Chang, L.-S., Welling, D.B. 2012. Preclinical Validation of AR42, a Novel Histone Deacetylase Inhibitor, as Treatment for Vestibular Schwannomas. Laryngoscope 122:174-189. PMID: 22109824
7. Bush, M.L., J. Oblinger, V. Brendel, G. Santarelli, C. Hrelec, J. Davis, J. Huang, E.M. Akhmametyeva, S.S. Burns, S. Kulp, C.-S. Chen, M. Giovannini, L.-S. Chang, D.B. Welling, A. Jacob. 2011. HDAC42, A Novel Histone Deacetylase Inhibitor, as a Potential Therapy for Vestibular Schwannomas and Meningiomas. Neuro-Oncology 13:983-989. PMID: 21778190
8. Bush, M.L., S.S. Burns, J. Oblinger, S. Davletova, L.-S. Chang, D.B. Welling, A. Jacob. 2012. Treatment of Vestibular Schwannoma Cells with ErbB Inhibitors. Otol. Neurotol. 33:244-257. PMID: 22222570
9. Chai, G., N. Liu, J. Ma, H. Li, J.L. Oblinger, A.K. Prahalad, M. Gong, L.-S. Chang, M. Wallace, D. Muir, A. Guha, R.J. Phipps, J.M. Hock, X. Yu. 2010. MicroRNA-10b Regulates Tumorigenesis in Neurofibromatosis Type 1. Cancer Sci. 101:1997-2004. PMID: 20550523
10. Omelyanchuk, L.V., J.A. Pertseva, S.S. Burns, and L.-S. Chang. 2009. Evolution and Origin of HRS, a Protein Interacting with Merlin, the Neurofibromatosis 2 Gene Product. Gene Regul. Syst. Biol. 3: 143-157. PMID: 20054405 (PMC2796970)
11. Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp S, Chen C-S, Giovannini M, Jacob A, Welling DB, Chang L-S. 2009. Growth Inhibitory and Anti-Tumor Activities of OSU-03012, a Novel PDK1 Inhibitor, on Vestibular Schwannoma and Malignant Schwannoma Cells. Eur. J. Cancer 45:1709-1720. PMID: 19359162 (PMC2692816)
12. Dorogova, N.V., E.M. Akhmameteva, S.A. Kopyl, N.V. Gubanova, O.S. Yudina, L.V. Omelyanchuk, and L.-S. Chang. 2008. The Role of Drosophila Merlin in Spermatogenesis.  BMC Cell Biol. 9: 1-15. PMID: 18186933
13. Jacob, A., T.X. Lee, B.A. Neff, S. Miller, D.B. Welling, and L.-S. Chang. 2008. Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma. Otol. Neurotol. 29:58-68. PMID: 18199958
14. Chang, L.-S., A. Jacob, M. Lorenz, J. Rock, E.M. Akhmametyeva, G. Mihai, P. Schmalbrock, A.R. Chaudhury, R. Lopez, J. Yamate, M.R. John, H. Wickert, B.A. Neff, E. Dodson, and D.B. Welling. 2006. Growth of Benign and Malignant Schwannoma Xenografts in Severe Combined Immunodeficiency Mice. Laryngoscope 116:2018-2026. PMID: 17075413
15. Akhmametyeva, E.M., M.M. Mihaylova, H. Luo, S. Kharzai, D.B. Welling, and L.-S. Chang. 2006. Regulation of the NF2 Gene Promoter Expression during Embryonic Development. Dev. Dyn. 235:2771-2785. PMID: 16894610