Dr. Li Xu
Northwestern University, USA

Email: lixu@northwestern.edu

Qualifications
1999 Ph.D., Fourth Military Medical University

1993 M.D., Fourth Military Medical University

Publications (Selected)

1. Xu L, Ding Y, Catalona WJ, Yang XJ, Anderson WF, Jovanovic B, Wellman K, Kilmer J, Huang X, Scheidt KA, Montgomery RB, Bergan RC. MEK4 function, genistein treatment, and invasion of human prostate cancer cells. J Natl Cancer Inst. 2009, 101(16):1141-55. PMCID: PMC2728746
2. Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, and Bergan RC. Dietary genistein inhibits metastasis of human prostate cancer in mice. Cancer Research.  2008, 68(6):2024-32.  PMID: 18339885
3. Craft CS, Xu L, Romero D, Vary CP and Bergan RC. Genistein induces phenotypic reversion of endoglin deficiency in human prostate cancer cells. Molecular Pharmacology. 2008, 73(1):235-242.  PMID: 17951357
4. Ding Y, Xu L, Jovanovic BD, Helnowski IB, Kelly DL, Catalona WJ, Yang XJ, Pins M, and Bergan RC. The methodology used to measure differential gene expression affects the outcome. Journal of Biomolecular Techniques.  2007, 18(5):321-330. PMID: 18166675
5. Xu L, Chen S and Bergan RC. MAPKAPK2 and HSP27 -dependent cell invasion in human prostatebare downstream mediators of TGF cancer.  Oncogene. 2006, 25(21):2987-2998. PMID: 16407830
6. Xu L and Bergan RC.  Genistein inhibits MMP-2 -mediatedbactivation and prostate cancer cell invasion by blocking TGF activation of the MAPKAPK2-HSP27 pathway. Molecular Pharmacology.  2006, 70(3):869-877. PMID: 16772519    
7. Ding Y, Xu L, Chen S, Jovanovic BD, Helnowski IB, Kelly DL, Catalona WJ, Yang XJ, Pins M, Ananthanarayanan V and Bergan RC.  Characterization of a method for profiling gene expression in cells recovered from intact human prostate tissue using RNA linear amplification. Prostate Cancer and Prostatic Diseases. 2006, 9(4):379-391. PMID: 16786039, PMCID: PMC2392989
8. Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC and Bergan RC.  Genistein inhibits p38 MAP kinase activation, MMP-2, and cell invasion in human prostate. Cancer Research. 2005, 65(8):3470-3478. PMID: 15833883
9. Xu HY, Xu L, Li KZ, Gao JH, and Yue SQ and Wang XX. In vivo and in vitro effects of chimeric Carcinoembryonic antigen anchored T-cell against gastric cancer. Chinese Journal of Surgery.  2008, 46(2): 148-149
10. Xu HY, Xu L, Gai JH, Li KZ and Dou KF. T lymphocytes with chimeric receptor induce carcinoembryonic antigen-positive specific gastric carcinoma cells apoptosis. National Medical Journal of China.  2007, 87(15):1053-1057. PMID: 17672971
11. Xu HY, Xu L, Gai JH, Li KZ and Dou KF. Construction of hepatocellular carcinoma-specific expression vector for anti-angiogenesis therapy.  Chinese Journal of Bases and Clinics in General Surgery. 2007, 14(1):15-18.
12. Xu HY, Xu L, Gai JH, Yang JJ and Li KZ. Detection of TAG-72 expression in human primary gallbladder carcinoma. Shandong Medical Journal (Chinese).  2007, 47(3):16-18.
13. Xu HY, Xu L, Li KZ  and Gai JH. Expression of anti-tumor-associated glycoprotein-72 single-chain variable fragment in human breast cancer cells.  Chinese Journal of Bases and Clinics in General Surgery. 2006, 13(5):540-541, 549.
14. Xu HY, Xu L, Gai JH, Yang JJ, Li KZ and Dou KF. Prokaryotic expression of anti-carcinoembryonic single-chain variable fragment and its value in detection of gastric carcinoma cells.  World J of Gastroenterology.  2006, 14(18):1780-1784.
15. Zhou XM, Han Y, Yang Y, Wang X, Xu L, Qiu JW, Miao JY, Wu KC, Ding J and Fan DM. Molecular Adsorbent Recirculating System application in 14 patients with drug-induced Liver Failure. Journal of the Fourth Military Medical University.  2006, 27(3):256-258.
16. Zhou XM, Miao JY, Yang Y, Zhao L, Wang X, Xu L, Ding J, Wu KC, Fan DM and Wang MM.  Clinical experience with Molecular Adsorbent Recirculating System (MARS) in patients with drug-induced liver failure. Artif Organs. 2004, 28(5):483-486.  PMID: 15113343
17. Zhou XM, Miao JY, Yang Y, Zhao L, Wang X, Xu L, Wu KC, Ding J and Fan DM.  Clinical investigation of treatments using Molecular Adsorbent Recirculating system (MARS) on 48 patients with acute-on-chronic liver failure.  Chinese Journal of Dialysis and Artificial Organs. 2004, 15(2):10-15.
18. Xu L, Xu HY and Fan DM. Construction a fusion molecular with T cell receptor for activation of carcinoembryonic antigen specific cytotoxic T lymphocytes to gastrointestinal tumors. Chinese Journal of Digestion.  2004, 24 (2):75-77.
19. Ning XX, Wu KC, Li Y, Shi YQ, Xu L, Qiao TD, Chen BJ and Fan DM. Study on immune response induced by the fusion gene vaccine of gastric cancer MG7-Ag mimotope and heat shock protein 70 in mice.  Medical Journal of Chinese People’s Liberation Army. 2004, 29(3):240-242.
20. Xu L, Jin BQ and Fan DM. Selection and identification of mimic epitopes for gastric cancer-associated antigen MG7 Ag. Molecular Cancer Therapeutic. 2003, 2(3):301-306. PMID: 12657725
21. Ning XX, Wu KC, Guo CC, Li Y, Shi YQ, Xu L, Han ZY, Liu N, Qiao TD, Chen BJ, Fan DM.  Immunological Characterization of a DNA vaccine of gastric cancer-related MG7-Ag mimotope fused with heat shock protein 70.  J Tumor Marker Oncology. 2003, 18:53-60.
22. Xu L and Wu KC. Clinical case discussion: a rare case of aggressive desmoid tumor. Chinese Journal of Internal Medicine.  2003, 42(3):286-288.
23. Xu HY, Xu L, Li KZ, Dou KF, Liu YF and Hinrich Abken. Molecular cloning of fuse gene to coactivate TAG-72 specific T lymphocytes. Chinese Journal of Experimental Surgery. 2003, 20(2):164-165.
24. Guo XG, Wang X, Wang BL, Xu L, Qiu JW, Wu KC, Ding J and Fan DM. Therapeutic effect comparison of octreotide and shanning on acute variceal bleeding in patients with cirrhosis-controlled trial. Journal of the Fourth Military Medical University. 2003, 24(20):1919.
25. Sun AP, Xu L and Lan HM. Peritoneal lavage therapy for 11 patients with severe acute pancreatitis. Chinese Journal of Medical Writing. 2003, 10(3):234-235.