Prof. Chang H.
Kim
Department of Comparative Pathobiology
Purdue
University, USA
Email: chkim@purdue.edu
Qualifications
1998 Ph.D., Indiana University School of Medicine
1992 MS, Korea
Advanced Institute of Science and Technology
1990 BS, Korea
Advanced Institute of Science and Technology
Publications
(Selected)
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Kim CH,Qu C,
Hangoc G,Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced
responses of immature and mature hematopoietic cells from motheaten mice:
Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses,
1999, J. Exp. Med., 190:681-690.
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Kim CH,Hangoc
G, Cooper S, Helgason CD, Yew S,Humphries RK, Krystal G,and Broxmeyer HE, Altered
responsiveness to chemokines due to targeted disruption of SHIP.1999, J. Clin.
Invest. 104:1751.
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Kim CH,
Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and
Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets
with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.
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Kim CH, Rott
LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC.Subspecialization of
CXCR5+ T cells: B helper activity is focused in a germinal center-localized
subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.
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Campbell DJ,
Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B
cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.
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Kim CH,Rott
LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of
chemokine receptor association with T cell polarization in vivo.2001, J. Clin.
Invest, 108:1331.
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Roy M, Kim CH,
Butcher EC. Cytokine regulation of B cell homing machinery.2002, J.
Immunol.169:1676.
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Kim CH,
Johnston B, Butcher EC. Trafficking machinery of NKT cells: shared and
differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT
cell subsets with distinct cytokine-producing capacity.2002, Blood. 100:11-6.
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Kunkel EJ, Kim
CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is
a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting
cells. 2003, J Clin Invest. 111:1001-10.
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Broxmeyer HE,
Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic
expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances
myeloid progenitor cell survival/antiapoptosis in vitro in response to growth
factor withdrawal and enhances myelopoiesis in vivo. 2003,J Immunol. 170:421-9.
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Kim CH, Nagata
K, and Butcher EC. Dendritic cells support sequential reprogramming of
chemoattractant receptor profiles during naive to effector T cell
differentiation. 2003, J. Immunol.171: 152-158.
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Kim CH, Lim
HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of
human germinal center T helper cells.2004, Blood. 104:1952-60.
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Lim HW,
Hillsamer P, Kim CH. Regulatory T cells can migrate to follicles upon T cell
activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
2004, J Clin Invest. 11:1640-9.
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Lim HW,
Hillsamer P, Banham AH, Kim CH. Cutting Edge: Direct suppression of B cells by
CD4+CD25+ regulatory T cells. J Immunol 2005 175: 4180-4183.
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Lim HW,
Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human
FOXP3+ regulatory T cells. J Immunol. 2006, 177(2):840-51.
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Kang SG,
Piniecki RJ, Lim HW, HogenEsch H, Braun SE, Wiebke E, Matsumoto S, Kim CH.
Identification of a chemokine network that recruits FoxP3+ regulatory T cells
to inflamed intestine. Gastroenterology, Volume 132, 2007, 966-981.
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Lee JH, Kang
SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue
homing receptors in thymus but accelerated second switch to non-lymphoid tissue
homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178:
301-311.
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Kang SG, Lim
HW, Andrisani OM, Broxmeyer HE, and Kim CH. Vitamin A Metabolites Induce Gut
Homing FoxP3+ Regulatory T cells. J Immunol 2007. 179: 3724-3733.
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Lim HW, Kim
CH. Loss of IL-7Ralpha defines terminally differentiated B cell helping
effector T cells. J Immunol, 2007. 179: 7448-7456.
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Lim HW,
Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with
both polarized effector T cells and FoxP3+ regulatory T cells. J Immunol, 2008.
180:122-9.
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Wang C, KangSG
, Lee JH, Sun Z,Kim CH. The role of CCR6 in migration of Th17 cells and
regulation of effector T cell balance in the gut.Mucosal Immunology.2009.
(2):173-83.
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Kang SG, Wang
C, Matsumoto, S, Kim CH. High and low vitamin A therapies induce distinct
FoxP3+ T cell subsets and effectively control intestinal inflammation.Gastroenterology.
2009 Oct;137(4):1391-402.
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Lee JH, Wang
C, Kim CH. FoxP3+ Regulatory T cells Restrain ExtramedullaryMyelopoiesis via
Suppression of Hematopoietic Cytokine-Producing T Cells. J Immunol. 2009 Nov
15;183(10):6377-86.
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Wang C, Kang
SG, HogenEsch H, Love PE, Kim CH.Retinoic acid determines the precise tissue
tropism of inflammatory Th17 cells in the intestine.J Immunol. 2010
184(10):5519-26.
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Betz BC,
Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH,Taparowsky
EJ.Batf coordinates multiple aspects of B and T cell function required for
normal antibody responses. J Exp Med. 2010, 207(5):933-42.
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Kang SG, Park
J, Cho JY, Ulrich B, Kim CH. Complementary roles of retinoic acid and TGF-beta1
in coordinated expression of mucosal integrins by T cells.Mucosal Immunol. 2011.
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Lee JH, Ulrich
B, Cho J, Park J, Kim CH.Progesterone promotes differentiation of human cord
blood fetal T cells into T regulatory cells but suppresses their
differentiation into th17 cells.J Immunol. 2011 Aug 15;187(4):1778-87.