Predictability and Management of OARs Toxicity in Patients with Prostate Cancer Treated with High-Dose Radiotherapy

Vincenzo Ravo, Domenico Borrelli, Sara Falivene, Rossella Di Franco, Matteo Muto, Angela Argenone, Valentina Borzillo, Fabrizio Cammarota, Paolo Muto

Radiotherapy Emicenter, Naples, Italy.
Radiotherapy of Second University of Naples, Naples, Italy.
Radiotherapy Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale”—IRCCS, Naples, Italy.

DOI: 10.4236/jct.2013.410174                

Abstract

Aim: To evaluate the predictability of toxicity analyzing the dose-volume histograms (DVHs) and to verify the effectiveness of preventive measures limiting side toxicity considering the evolution of the radiation techniques for prostate cancer treatment. Materials and Methods: 208 patients with localized prostate cancer were treated with exclusive radiotherapy until 73.8 Gy (group A) or 79.2 Gy (group B) with the dose escalation technique. Preventive measures to minimize the side effects were recommended in group B. Results: The assessment of genitourinary toxicity was similar while gastrointestinal toxicity was better in group B. Valuating the treatment plans, we found that most of the patients developing toxicity had “borderline” DVHs. Conclusion: Our analysis led to the establishment of a protocol for the management of patients with “border-line” DVH.

Keywords

Toxicity; Radiotherapy; Prostate Cancer; Prevention

Conflicts of Interest

The authors declare no conflicts of interest.

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