Background: The elderly cancers are worldwide a major public health issue. Their exact incidence is unknown in Togo. The purpose of this study was to describe epidemiological and histological data of cancers in the elderly in Togo. Materials and Methods: This was a cross-sectional and descriptive study of cases of elderly cancers diagnosed at the laboratory of pathology of the university teaching hospital of Lomé from 1995 to 2014 (20 years). Cases of examination on samples of the elderly (biopsy, excision, surgical specimens) were collected from the data records of that laboratory. Results: Overall, 792/5200 cases of elderly cancer were collected representing 15.2% of all cancers diagnosed in the laboratory. The annual incidence was 39.6 cases. Patient age ranged from 65 to 103 years old, with a mean of 68.5 ± 4 years old. The sex ratio (M/F) was 1.3. At pathological level, the study material included pieces (n=290 cases; 36.6%) and biopsies (n=502 cases; 63.4%). Cancers located preferably in prostate in men (38%), and in women the most frequent locations were cervix (16.2%) and breast (15.8%). We noticed four histological groups: carcinomas (n = 706 cases; 89.1%), sarcomas (n = 43 cases; 5.5%), lymphoma (n = 34 cases; 4.3%) and melanoma (n = 9 cases; 1.1%). Carcinomas were dominated by adenocarcinomas (50.1%) and squamous cell carcinomas (33.8%); Kaposi’s sarcoma (32.6%) was the most common histological type in sarcomas. Conclusion: Our results showed that the elderly cancers were frequent in Togo, locating mostly in uterus cervix and breast in female, and prostate in men. This study could help to advocate the establishment of a cancer registry in Togo.
Cancers are a real public health issue. They affect individuals of all ages, but the risk of occurrence and related deaths to cancer rise sharply with age [
The purpose of this study was to describe the epidemiological and histological aspects of cancer among subjects aged 65 and over in Togo. These data could help to strengthen advocacy for the establishment of a registry of cancer.
We conducted a retrospective and descriptive study of all cases of cancer among subjects aged 65years and older diagnosed between January 1995 and December 2014 (20 years) in the laboratory of pathology of the university teaching hospital of Lomé. These cases were collected from the records of that laboratory. The samples examination techniques consisted primarily of paraffin embedded (56˚C - 60˚C) and then stained with hematoxylin eosin. The variables studied were epidemiological (gender, age, origin) and histological data (seat, histological type).
Categorical variables are expressed as counts and percentages and continuous variables are expressed as means and standard deviations (SDs). The processing and data analysis were performed using Epi Info version 3.5.1.
The confidentiality of data banks has been respected according to the ethical rules in force in Togo. This studyreceived approval from theHead of the laboratory department tobe conducted. Since it was counting records, patient consent was not required. However during the countingand data collection patient names were notcollectedin order to preserveconfidentiality.
We collected during our study period 792 cases of elderly cancer representing 15.2% (5200 cases) of all cancers diagnosed in the Laboratory. The annual incidence was 39.6 cases. We observed 454 cases (57.3%) of males and 338 cases (42.7%) of male subject about a sex ratio (M/F) of 1.3. Patient age ranged from 65 to 103 years old, with a mean of 68.5 ± 4 years old. Among males, the mean age was 66.4 ± 9 years old and mean age was 71.2 ± 3 years old among females. The topographic distribution showed that these cancers preferentially sit in humans to the prostate (n = 171 cases; 38%) and stomach (n = 55 cases; 12.1%); in women the cervix (n = 55 cases; 16.2%) and breast (n = 54 cases; 15.8%) were the most represented sits (
The studied samples were 502 cases (63.4%) of biopsies and 290 cases (36.6%) of surgical specimens. The overall distribution of elderly cancer noted four histological groups: carcinomas (n = 706 cases; 89.1%), sarcomas (n = 43 cases; 5.5%), lymphoma (n = 34 cases; 4.3%) and melanoma (n = 9 cases; 1.1%). Cancers were at a localized stage in 11 cases, all of which 7 carcinoma in situ localized in the breast and 4 in the cervix. Carcinomas were observed at a mean age of 67.4 years, distributed in 397 cases (56.2%) of males and 309 cases (43.8%) of female. The histological types are shown in
Sarcomas in the elderly were observed at a mean age of 73.6 years old, distributed in 24 cases (55.8%) in men and 19 cases in women (44.2%). These sarcomas sat in the skin (n = 35cases; 81.4%), digestive tract (n = 5 cases;
Male | Female | Male + Female | ||||
---|---|---|---|---|---|---|
Seats | Number | % | Number | % | Number | % |
Lips | 2 | 0.44 | 1 | 0.30 | 3 | 0.38 |
Language | 7 | 1.55 | 2 | 0.59 | 9 | 1.14 |
Mouth | 4 | 0.88 | 2 | 0.59 | 6 | 0.76 |
Salivary Gland | 3 | 0.66 | 1 | 0.30 | 4 | 0.51 |
Pharynx | 7 | 1.55 | 3 | 0.89 | 10 | 1.26 |
Esophagus | 30 | 6.61 | 6 | 1.78 | 36 | 4.55 |
Stomach | 55 | 12.11 | 31 | 9.17 | 86 | 10.86 |
Small intestine and colon | 10 | 2.20 | 9 | 2.66 | 19 | 2.40 |
Rectum and anal canal | 20 | 4.40 | 14 | 4.14 | 34 | 4.29 |
Liver and biliary | 1 | 0.22 | 5 | 1.48 | 6 | 0.76 |
Pancréas | 3 | 0.66 | 1 | 0.30 | 4 | 0.51 |
Nasal et sinus Fosse | 4 | 0.88 | 6 | 1.78 | 10 | 1.26 |
Larynx | 9 | 1.98 | 7 | 2.07 | 15 | 1.89 |
Trachea, bronche, lungs | 10 | 2.20 | 8 | 2.37 | 18 | 2.27 |
Bone and cartilage | 14 | 3.08 | 11 | 3.25 | 25 | 3.16 |
Skin | 20 | 4.41 | 19 | 5.62 | 39 | 4.93 |
Soft tissue | 25 | 5.51 | 25 | 7.40 | 50 | 6.31 |
Breast | 6 | 1.32 | 54 | 15.98 | 60 | 7.58 |
Vulva | - | - | 3 | 0.89 | 3 | 0.38 |
Vagina | - | - | 2 | 0.59 | 2 | 0.22 |
Cervix | - | - | 55 | 16.27 | 55 | 6.94 |
Utérine body | - | - | 32 | 9.47 | 32 | 4.04 |
Ovary | - | - | 2 | 0.59 | 2 | 0.25 |
Prostate | 171 | 37.67 | - | - | 171 | 21.59 |
Kidney | 1 | 0.22 | 3 | 0.89 | 4 | 0.51 |
Bladder | 6 | 1.32 | 4 | 1.18 | 10 | 1.26 |
Eye | 1 | 0.22 | 5 | 1.48 | 6 | 0.76 |
Thyroid | 1 | 0.22 | 1 | 0.30 | 2 | 0.25 |
Unclear Seat | 9 | 1.98 | 13 | 3.85 | 22 | 2.78 |
Lymphoid tissue | 25 | 5.51 | 23 | 6.80 | 48 | 6.06 |
All seats | 454 | 100 | 338 | 100 | 792 | 100 |
11.6%) and breast (n = 3 cases; 7%). The histological types were dominated by Kaposi’s sarcoma (n = 14 cases; 1.8%) and dermatofibrosarcoma (n = 10 cases; 1.3%) (
Hodgkin lymphomas (HL) were seen in 4 cases and non-Hodgkin in 30 cases. Non-Hodgkin lymphoma (NHL) was dominated by diffuse large B-cell lymphomas (n = 22 cases; 73.33%). Other lymphomas consisted of Malta lymphoma (n = 6 cases; 20%) and T-cell lymphoma (n = 2 cases; 6.67%). The cases of HL were all classic
Histological types | Number of cases (n) | Percentage (%) |
---|---|---|
Carcinomas (n = 706) | ||
Adénocarcinoma | 354 | 44.70 |
Squamous cell carcinoma | 239 | 30.18 |
Infiltrating ductal carcinoma | 59 | 7.45 |
Adenoid cystic carcinoma | 11 | 1.39 |
Mucinous carcinoma | 9 | 1.14 |
Papillary carcinoma | 7 | 0.88 |
Transitional cell carcinoma | 6 | 0.76 |
Clear cell carcinoma | 3 | 0.38 |
Undifferentiated carcinoma | 2 | 0.25 |
Sarcomas (n = 43) | ||
Kaposi sarcoma | 14 | 1.77 |
Dermatofibrosarcoma | 10 | 1.26 |
Fibrosarcoma | 8 | 1.01 |
Rhabdomyosarcoma | 5 | 0.63 |
Leiomyosarcoma | 3 | 0.38 |
Liposarcoma | 3 | 0.38 |
Lymphomas (n = 34) | ||
LNH | 30 | 3.79 |
LH | 4 | 0.51 |
Melanomas | 9 | 1.14 |
All of cases | 792 | 100 |
shape (3 nodular sclerosis form and 1 form of lymphocyte depletion).
Nine cases of melanoma were observed of which 8 were located in the lower limbs and 1 in the upper limbs; these melanoma were all observed in 5 men.
The rates of elderly cancer present significant variations through the world. Indeed, data found in northern countries with high technical platform and cancer registries are hardly comparable to those observed in Southern countries in which cancer registry is not available. The continuous and comprehensive record of all cases of cancer (cancer registry) is a guarantor of the quality of data and allows an approach to estimate the impact and the different epidemiological settings [
Thus, in our study, the elderly cancers represented 15.2% of all cancers, comparable to the rate reported in Congo-Nkoua M’Bon which was 17.4%, but very low compared to rates observed in Europe (60%) and USA (65%) [
The average age of patients in our study is similar to those of African authors where seniors account for only 5% - 10% of the whole population [
Carcinomas were the most frequent histological group in our study, dominated by prostatic adenocarcinoma and digestive localizations. The predominant histological type was invasive ductal carcinoma, and in squamous cell carcinoma in the cervix. Indeed, if there is evidence of reduced mortality factors for breast cancer, colorectal cancer and cervical cancer through screening in the population under 65, few studies have included people of 70 and over [
Sarcomas represented the second histological group of elderly cancer, dominated by Kaposi’s sarcoma. It is endemic in Africa with variable rates between 4 and 38% versus rates below 1% in Asia and Europe [
Melanomas in the elderly were uncommon in our study (1.14%), confirming the trend that it is a rare disease in the black race. In South Africa, its rates vary between 0.5 and 1.8 cases per year per 100,000 population among black Africans against 4.4 to 6.2 per 100,000 per year in whites people [
The elderly cancers are frequent in our country, in spite of the quality of data available because of lack of cancer registry. Prostate cancer in men, cervical and breast cancers in women were the most common cancer in the elderly. This study also allowed us to have knowledge on different histological types of elderly cancer dominated by adenocarcinomas. In light of this work, we advocate the installation of a cancer registry and the establishment of a free cancer care in the elderly.
The authors reported no conflict of interest.
TD: supervised for the design of the study, undertook the field study, performed data collection, analysis and interpretation of the results, and wrote the manuscript. AW, TMK, ASA, NM, and MK participated in the design of the study, supervised the data collection and participated in the data analysis. KA and NG were responsible for the overall scientific management of the study, the analysis and interpretation, and preparation of the final manuscript. All authors have read and approved the final manuscript to be submitted for publication
TchinDarré,AtchiWalla,Tchilabalo MatchonnaKpatcha,Abdoul-SamadouAboubakari,NidainManeh,MikotakatolaKoulinga,KoffiAmégbor,Gado NapoKoura, (2016) Cancers in the Elderly Seen in Anatomical Pathology Laboratory in Lomé, Togo. Open Journal of Pathology,06,26-31. doi: 10.4236/ojpathology.2016.61005