TITLE:
Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan Murraya koenigii (L.) Spreng
AUTHORS:
Kartini Ahmad, Siow-Ping Tan, Mohd Aspollah Sukari, Abdul Manaf Ali, Mohd Azlan Nafiah
KEYWORDS:
Carbazole, Rutaceae, Murraya koenigii, NMR, Cytotoxic
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.5 No.19,
September
12,
2014
ABSTRACT: Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian
origin and now is widely distributed throughout southern Asia. The stem bark,
leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated
and identified using spectroscopic methods including NMR, IR, UV, MS spectra
data. Crude extract and isolated compounds from the roots of this plant were
screened for cytotoxic activity and antitumor promoting activity. All crude
extracts of the roots including the isolated compounds, mahanimbine, mahanine
and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS
cell line with IC50 3mg/mL. Girinimbine
inhibited EBV-activation in the antitumor promoting assay.