TITLE:
Dietary Combination of Fish Oil and Hemoglobin Hydrolysates Alters Serum and Liver Lipid Contents in Rat
AUTHORS:
Kenji Fukunaga, Noriko Yukawa, Ryota Hosomi, Toshimasa Nishiyama, Munehiro Yoshida
KEYWORDS:
Fish Oil; n-3 Polyunsaturated Fatty Acid; Hemoglobin Hydrolysates; Lipid Metabolism
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.9A,
August
30,
2013
ABSTRACT:
Fish oil has been shown to have
anti-inflammatory and anti-cancer effects, and to reduce serum triacylglycerol
(TAG) levels by stimulating lipid oxidation and inhibiting lipogenesis in the
liver. A small number of studies have demonstrated the synergistic effect of
fish oil and other bioactive components. This study examined the effect of fish
oil in combination with porcine hemoglobin (Hb) hydrolysates on serum and liver
lipid contents in rats. Male Wistar rats were divided into four groups; one
group was fed a casein and soybean oil-based semi-purified basal diet and other
three groups were fed the basal diet supplemented with 2% fish oil, 0.175% Hb
hydrolysates, and 2% fish oil plus 0.175% Hb hydrolysates, respectively, for 4
weeks. The fish oil diet decreased serum and liver TAG contents but did not
change serum and liver cholesterol levels. The dietary combination of fish oil
and Hb hydrolysates decreased serum and liver TAG and cholesterol contents
owing to the additive effect of both compounds, and this diet reduced the serum
non-high-density lipoprotein cholesterol content as a result of a synergistic
effect. This hypolipidemic effect was in part caused by enhanced excretion of
fecal fatty acids, neutral steroids, and acidic steroids. The results of this
study suggest that the combined intake of fish oil and Hb hydrolysates may play
beneficial roles in the prevention of cardiovascular disease as compared with
fish oil alone.