TITLE:
Long Lasting Efficiency of Monthly Vinblastine in a Case of Relapsed Anaplastic Large Cell Lymphoma
AUTHORS:
Ratha Mlis, Matthias Schell, Perrine Marec Bérard, Nathalie Bleyzac, Didier Frappaz
KEYWORDS:
Anaplastic Large Cell Lymphoma; Vinblastine
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.3 No.2,
June
25,
2013
ABSTRACT: Nearly 40% of children with Anaplastic Large cell lymphomas will relapse after a first-line strategy with short-pulse chemotherapy and reach a second remission in 30% to 60% with second line therapies including maintenance treatment with vinblastine or allogeneic hematopoietic stem-cell transplantation. The authors report a heavily pretreated case in second relapse who was maintained in third remission for 8 years with monthly vinblastine. He relapsed 16 weeks after discontinuation. This case demonstrates that monthly treatment with vinblastine may be sufficient to maintain a minimal disease. Oral compounds are now available and should be discussed in such situations.