G. B. Zhou, H. Kang, L. Wang, L. Gao, P. Liu, J. Xie, F. X. Zhang, X. Q. Weng, Z. X. Shen, J. Chen, L. J. Gu, M. Yan, D. E. Zhang, S. J. Chen, Z. Y. Wang and Z. Chen, “Oridonin, a Diterpenoid Extracted from Medicinal Herbs, Targets AML1-ETO Fusion Protein and Shows Potent Antitumor Activity with Low Adverse Effects on t (8;21) Leukemia in Vitro and in Vivo,” Blood, Vol. 109, No. 8, 2007, pp. 3441-3450. doi:10.1182/blood-2006-06-032250

has been cited by the following article:

• TITLE: Effects of Root Extracts from Panax ginseng C. A. Meyer (Araliaceae) of Different Ages on K562 Cells

  AUTHORS: Xunan Lyu, Yizhen Zhang, Qing Mu, Zhou Cheng, Jiakuan Chen, Wenju Zhang

  KEYWORDS: Panax ginseng; Root Extracts; Ages; K562 Cell Line

  JOURNAL NAME: American Journal of Plant Sciences, Vol.4 No.6, June 25, 2013

  ABSTRACT: It is well accepted in China that elder ginsengs have more bioactivity and value than younger ones. However, there is little research about the comparison of beneficial effects of ginsengs with different ages. In this study, ginseng root extracts (GRE) were extracted from ginsengs of 5, 8, 12, 14, and 16 years old, respectively, using 55% ethanol and their effects on human leukemic K562 cells within 48 hours were tested by using Cell Counting Kit-8. The results show that there are significant increases in the cell viability of all the GRE groups compared with Control group within 32 hours. Furthermore, the growth curves of GRE groups were obviously distinct from each other. The cell viability of 5-year-old and 8-year-old GRE groups kept a rapid increase while that of 16-year-old GRE group showed a strong fluctuation within 28 hours. Our results demonstrate that root extracts from ginsengs of different ages contain different bioactivity constituents and have different effects on cell.