TITLE:
Clinical use of estimating glomerular filtration rate equ-ations during pregnancy
AUTHORS:
Luiz Paulo José Marques, Regina Rocco, Maria Helena Victor, Benedita Calheiros de Novaes, Ana Luiza Batista de Carvalho, Omar da Rosa Santos
KEYWORDS:
Pregnancy, Kidney function, Glomerular Filtration Rate, MDRD equation, Cockcroft-Gault equation.
JOURNAL NAME:
Health,
Vol.3 No.1,
January
29,
2011
ABSTRACT: Background: Kidney disease, even when mild, was once considered so major an impediment to successful pregnancy and so dangerous to the mother’s wellbeing. High-risk pregnancy mainly associated to renal impairment may occur in 10-20% of gestations and it is very important that renal function is closely monitored to prevent or minimize maternal and fetal complications. This study was designed to investigate the performance of Cockcroft-Gault CGeq and the simplified MDRDeq equations in healthy pregnant women to assess renal function. Methods: We studied 167 normal ambulatory pregnant women and kidney function was contemporaneously estimated through the CGeq and the simplified MDRDeq and calculated through the creatinine clearance (Ccr). Serum and urinary creatinine were assayed using Jaffé reaction method in the same AutoAnalyser. Results: When we compared calculated and estimated clearences for measurement of kidney function we observed that CGeq overestimated renal function (CGeq = 168.41 ± 38.80 ml/ min/1.73 m2, Ccr = 146.27 ± 30.49 ml/min / 1.73 m2, p