Article citationsMore>>
Capparelli, R., Alfano, F., Amoroso, M.G., Borriello, G., Fenizia, D., Bianco, A., Roperto, S., Roperto, F. and Iannelli, D. (2007) Protective effect of the NRAMP-1 BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis). Infection and Immunity, 75, 988-996.
doi:10.1128/IAI.00948-06
has been cited by the following article:
-
TITLE:
Tyrosine phosphorylation of monocyte-derived macrophage proteins in buffalo (Bubalus bubalis): A potential phenotype of natural resistance
AUTHORS:
Maria Miarelli, Federica Signorelli, Giovanna de Matteis
KEYWORDS:
Buffalo; Macrophage; Natural Resistance; Tyrosine Phosphorylation
JOURNAL NAME:
Open Journal of Animal Sciences,
Vol.3 No.2,
April
18,
2013
ABSTRACT:
The aim of this work was to explore the possibility of using the presence of
tyrosine-phosphorylated macrophage proteins as a phenotype of
natural resistance. Tyrosine-phosphorylation of macrophage proteins was
investigated in 18 buffaloes, that carried either the resistant, or the
non-resistant, Natural Resistance-Associated Macrophage Protein one (NRAMP1)
genotype, that various authors have associated with susceptibility to
intracellular bacterial diseases. Monocyte-derived macrophages were
Interferon-gamma (IFN-γ) stimulated and tyrosine-phosphorylation was
assessed by Western blotting. Evidence of phosphorylation after IFN-γ stimulation was shown by 75% of the
buffaloes carriers of the resistant genotype, and by 20% of the carriers of the
non-resistant genotype (Chisquare value between the groups = 5.44; P = 0.02).
The study of the Proteoma of monocyte-derived macrophages might open the way
to the genetic control of disease resistance.
Related Articles:
-
Junda Lin
-
Moustafa Kotb, Mohamed Ibrahim Abdel Razik, Reda Abbass Sabry
-
Zijun Ma, Meilin Xu, Kaiqin Jin, Guangfu Zhu, Xin Chen
-
Xiaoyu Liu, Duyun Peng, Youdong Wen
-
Anqi Wang