TITLE:
Identification of the Bacterial Gene in Patients Who Repeatedly Develop Streptococcal Pharyngitis
AUTHORS:
Yuichiro Tsuji, Ichihashi Izumi
KEYWORDS:
Bacterial Gene; Cefcapene Pivoxil; PFGE (Pulse-Field Gel Electrophoresis); Reinfection; Streptococcal Pharyngitis
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.3 No.7,
December
31,
2012
ABSTRACT:
Background: We aimed at determining whether the pathogenic bacteria at the
onset of disease are genetically different and whether this affects future
choice of the therapeutic methods against group A β-hemolytic streptococcal acute pharyngitis/tonsillitis. Methods: A pharynx swab was collected
from pediatric patients who visited our hospital. The swab was cultured, and
hemolytic streptococcus was detected 230 times. We isolated pathogenic bacteria
of patients infected more than once and examined the bacteria using pulse-field
gel electrophoresis. Results: Based
on gene search results, we found that if the period of developing relapse was
within 1 month from the first infection, all patients had the same gene.
However, all patients in whom reinfection occurred after 6 months or later had
different pertinent genes. Conclusions: The number of relapse/reinfection is significant for this disease, and
considerably caution is essential for its treatment. No changes to
antibacterial drug administration may be necessary for the second
administration unless more than 6 months have passed since the first infection.