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has been cited by the following article:

• TITLE: Is a Divergent Central Serotonergic Activity Responsible for Either Despair or Learning Behavior in Intact Wistar or Sprague-Dawley CD Rats, Respectively? A Concomitant Behavioral and Electrochemical Analysis

  AUTHORS: Francesco Crespi

  KEYWORDS: Rat Strains, Behavior, Electrochemistry, Fluoxetine, Serotonin, Platelets

  JOURNAL NAME: Psychology, Vol.1 No.3, August 24, 2010

  ABSTRACT: Behavioral observations combined with electrochemical analysis have been performed in Wistar or Sprague-Dawley CD rats in the attempt to clarify earlier controversial behavioral reports. In particular, these rats were submitted to FST and to repeated Forced Swimming (rFS, during 4 days). In parallel, voltammetric in vivo analysis of serotonin (5-HT) levels in platelet-rich plasma (PRP) collected daily from these animals was also performed as it is known that peripheral 5-HT levels monitored in rat PRP mirror cerebral 5-HT contents. Thus, combined behavioral-voltammetric studies allow deducing changes of central 5-HT levels that could be correlated to FST or rFS, with the advantage of non invasive analysis of central neurotransmitter activities in intact behaving animals. In particular, combined beha-vioral-voltammetric results suggest that “behavioral despair” is the process interesting Wistar rats when submitted to FST or rFS while “learning to be immobile” is the process involving Sprague-Dawley CD rats.