A. Rosowsky, C. E. Mota, S. F. Queener, “Synthesis and Antifolate Activity of 2,4-Diamino-5,6,7,8-tetrahydro- pyrido[4,3-d]pyrimidine Ana-logues of Trimetrexate and Piritrexim,” Journal of Heterocyclic Chemistry, Vol. 32, No. 1, 1995, pp. 335-340. doi:10.1002/jhet.5570320155

has been cited by the following article:

• TITLE: An Efficient Synthesis of Pyrido[2,3-d]pyrimidine Derivatives via One-Pot Three-Component Reaction in Aqueous Media

  AUTHORS: Shahrzad Abdolmohammadi, Saeed Balalaie

  KEYWORDS: Diammonium Hydrogen Phosphate (DAHP), Microwave Irradiation (MWI), Water in Organic Synthesis, Pyrido[2, 3-d]pyrimidine

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.2 No.1, March 15, 2012

  ABSTRACT: A series of pyrido[2,3-d]pyrimidines derivatives have been prepared by one-pot three-component reaction of 4(6)-aminouracil, malononitrile and aromatic aldehydes. This efficient synthesis was done under microwave irradiation conditions (method A) and also using catalytic amount of diammonium hydrogen phosphate [(NH4)2HPO4] (DAHP) in aqueous media (method B). This procedure has the advantages of good yields, easy work-up, and benign environmentally friendly character. Reaction could proceed via domino Knoevenagel-Michael-cyclization reactions.