Hong, L.T., Downes, K.J., FakhriRavari, A., Abdul-Mutakabbir, J.C., Kuti, J.L., Jorgensen, S., Young, D.C., Alshaer, M.H., Bassetti, M., Bonomo, R.A., Gilchrist, M., Jang, S.M., Lodise, T., Roberts, J.A., Tängdén, T., Zuppa, A. and Scheetz, M.H. (2023) International Consensus Recommendations for the Use of Prolonged-Infusion Beta-Lactam Antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 43, 740-777.
https://doi.org/10.1002/phar.2842

has been cited by the following article:

• TITLE: Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in Pseudomonas aeruginosa PAO1

  AUTHORS: Godspower Oghenemaroh Sebe, Supreme O. Oghenerhoro, Ogbole E. Jonathan, Ebuka Victor Anyaogu, Adeyemo David Adebowale, Raymond Chidozie Ntomchukwu

  KEYWORDS: Pseudomonas aeruginosa PAO1, Antibiotic Resistance, Next-Generation Antibiotics, Adjuvant Synergy, Intracellular Accumulation, Penetration Rates, Minimum Inhibitory Concentration (MIC), Resistance Tra-jectory, Fluorescence Quantification

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.16 No.8, August 30, 2023

  ABSTRACT: This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. Results showed a diminished potential for resistance emergence with Antibiotic B, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat.