TITLE:
Factors Associated with Hepatic Steatosis in Black African Subjects with Chronic Viral Hepatitis B in Côte d’Ivoire
AUTHORS:
Kouamé Hatrydt Guillaume Dimitri, Kissi Anzouan-Kacou Henriette Ya, Gogan Patricia, Bangoura Aboubacar Demba, Doffou Stanislas Adjeka, Mahassadi Kouame Alassan, Yao Bathaix Fulgence Mamert, Attia Alain Koffi
KEYWORDS:
Non-Alcoholic Fatty Liver Disease, Chronic Viral Hepatitis B, Obesity, Metabolic Syndrome, Fibroscan/CAP, Africa
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.13 No.10,
October
31,
2023
ABSTRACT: Context/Objectives: With the progression of the global epidemic of obesity and metabolic syndrome, the coexistence of hepatic steatosis in patients with chronic viral hepatitis B (VHB) is becoming significant. The aim of this work was to determine the factors associated with hepatic steatosis assessed by a Fibroscan with Controlled Attenuation Parameter (CAP) in patients with chronic viral hepatitis B in Côte d’Ivoire. Methods: This was a cross-sectional and analytical study. Data was collected from February 15 to July 31, 2020 in a private hospital structure in the city of Abidjan in Côte d’Ivoire. We included 83 patients with chronic viral hepatitis B. These were black patients, having performed a Fibroscan/CAP during the recruitment period and consenting to participate in the study. Patients with significant alcohol consumption, a secondary cause of hepatic steatosis, or other liver disease regardless of the etiology associated with hepatitis B were not included. Results: The frequency of hepatic steatosis in chronic VHB carriers assessed by the CAP in our study population was 48.19% including 24.10% severe steatosis. Obesity and high LDL cholesterol were statistically correlated with the presence of steatosis in our patients. Patients who had steatosis on ultrasound were 5 times more likely to have steatosis on CAP. Significant fibrosis was not significantly associated with steatosis. Conclusion: Obesity and LDL hypercholesterolemia are the main factors associated with hepatic steatosis detected by Fibroscan/CAP in patients with chronic viral hepatitis B.