TITLE:
Maternal Supplementation of Saccharomyces cerevisiae var. boulardii to Sows from Late Gestation through Lactation Impacts the Neutrophil Function of the Sow and the Innate Immune Status of Progeny Short-Term
AUTHORS:
Lily P. Hernandez, Janeen L. Salak-Johnson
KEYWORDS:
Immune, Maternal Supplementation, Piglet, Sow, Yeast Probiotic
JOURNAL NAME:
Open Journal of Animal Sciences,
Vol.13 No.4,
October
10,
2023
ABSTRACT: The primary objective of this study was to evaluate
the potential immunomodulatory effect of maternal supplementation of Saccharomyces
cerevisiae var. boulardii (Scb)
from late gestation until the end of lactation on the immune phenotype of her
progeny. Eighteen sows were fed 2 boluses per day of Saccharomyces
cerevisiae var. boulardii CMCN-1079 (probiotic; PRO, n = 9) or placebo (CON, n = 9) starting at gestational
day (GD) 84 and continuing until 21 days post-farrowing (end of lactation). Sow
blood samples were collected every 7 days post-supplementation during gestation
and 24-h post-farrowing and end of lactation. Blood samples were taken
from 84 female pigs (n = 42 per sow
treatment group) at 1, 7, 14, 21, 28, and 35 days old to assess innate and
adaptive immune measures. Minimal effects of Scb supplementation were found on
sow immune status during gestation and lactation, except for PRO-treated
sows that had enhanced neutrophil function (P and mitogen-induced lymphocyte proliferation
after 51 days of treatment (P neutrophil chemotaxis, NK cytotoxicity,
and mitogen-induced B-lymphocyte proliferation
than those from CON sows (P inimal effect on the sows but postnatal maternal
exposure to Saccharomyces cerevisiae var.
boulardii supplementation modulated the immune status of the progeny beyond
the lactation period resulting in those from PRO-treated sows having more
enhanced neutrophil function and B-cell proliferative response in the short
term. Therefore, these data imply that including yeast probiotics in maternal
diets may have carry-over effects in priming offspring’s immune function,
especially neutrophil function and B-cell proliferation in the short
term.