TITLE:
The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies
AUTHORS:
Peter K. Panegyres, Emily R. Atkins
KEYWORDS:
Amyloid Precursor Protein, APP, Genes, Dementia, Alzheimer’s Disease
JOURNAL NAME:
Neuroscience and Medicine,
Vol.2 No.4,
December
2,
2011
ABSTRACT: Pharmacological studies reveal APP and Aβ have interactions with glutamate and calcium, cytokines, copper/zinc chelators, secretases and presenilins, nicotinic receptors, acetycholinesterase, neurotrophins, non-steroidal anti-inflame-matory drugs, monoclonal antibodies to Aβ, protease inhibitors, oestrogen, homocysteine, immediate early genes such as c-fos or c-jun and cholesterol. These functional and pharmacological observations highlight the need for greater understanding of APP and Aβ in brain function and have implications for clinical trials.