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has been cited by the following article:

• TITLE: Tryptophan Metabolism and Gut Microbiota

  AUTHORS: Akikazu Takada

  KEYWORDS: Tryptophan, Serotonin, Microbiota, Depression, Obesity, Kynurenine, Blood Brain Barrier, Kynurenine, Permeability, Autism, Depression, Diabetes

  JOURNAL NAME: Food and Nutrition Sciences, Vol.14 No.8, August 28, 2023

  ABSTRACT: Background: Tryptophan metabolites such as serotonin, kynurenine, or kynurenic acids are considered to be the most important metabolites of gut microbiota. We wanted to know about changes in tryptophan metabolites in various diseases in which the etiology gut microbiota are considered to participate. Methods: Ultra-high speed liquid chromatography/mass spectroscopy (LC/MS) has been used to analyze simultaneously all the tryptophan metabolites, which we have explored for the first time in the world. Results: We analyzed plasma levels of tryptophan metabolites in patients with depression, autism, diabetes mellitus ‘DM’), and acute coronary syndrome (ACS). Of all the metabolites serotonin and kynurenine levels of these patients were higher than those of controls. Conclusion: Measurements of tryptophan metabolites in plasma of various diseases are important to know roles of gut microbiota in etiology, further therapeutic measures.