Bar-Zeev, N., Swarthout, T.D., Everett, D.B., Alaerts, M., Msefula, J., Brown, C., Bilima, S., Mallewa, J., King, C., von Gottberg, A., Verani, J.R., et al. (2021) Impact and Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine on Population Incidence of Vaccine and Non-Vaccine Serotype Invasive Pneumococcal Disease in Blantyre, Malawi, 2006–18: Prospective Observational Time-Series and Case-Control Studies. The Lancet Global Health, 9, e989-e998.
https://doi.org/10.1016/S2214-109X(21)00165-0

has been cited by the following article:

• TITLE: Trends in Bacterial Blood Culture Isolates and Resistance in Children in Two Microbiologic Eras from a Tertiary Health Facility in North East Nigeria

  AUTHORS: Elon Warnow Isaac, Iliya Jalo, Mohammed M. Manga, Abubakar Joshua Difa, Mercy Raymond Poksireni, Oyeniyi Christianah, Ibrahim Mohammed, Muhammad Saminu Charanci

  KEYWORDS: Trend, Blood Culture Isolates, Children, Manual, Bactec, Resistance

  JOURNAL NAME: Open Journal of Medical Microbiology, Vol.13 No.2, June 30, 2023

  ABSTRACT: Introduction: Antimicrobial Resistance surveillance is predicated on blood culture as a priority clinical specimen in especially resource limited settings. Establishing trends in blood stream infections and resistance patterns can inform institutional and national policy on antimicrobial stewardship, surveillance, infection prevention and control. Methodology: Blood Culture isolates in children (0 - 18 years) by conventional method from 2008-2012 and Bactec Automated culture system from 2015-2020 were retrieved. Information analyzed included age, sex, month, and year and culture growth/identity of microorganisms and their sensitivity/resistance patterns. Clinical and Laboratory Standards Institute (CLSI) guideline for antibiotic susceptibility testing was used. Results: 20,540 children were admitted: 8964 (44.6%) and 11,630 (55.4%) in the Manual and Bactec blood culture era respectively. Blood cultures were done in 5271 in the manual culture era and 1077 in the Bactec culture era; of these cultures, 514 (9.7%) and 461 (42.8%) were positive for isolates in the respective era (p = 0.01). There were no statistically significant differences in trend between positive and negative blood cultures in males and females. Newborns, followed by children 1 - 5 years had more blood culture performed on them than other age categories. In general, there is no significant relationship in blood culture outcomes between the age categories and sex of the patients. The isolation of Staph aureus, Citrobacter and Alkaligenes increased two-fold with Bactec automated system. Resistance to the quinolones and the penicillin was high. Resistance trend to Genticin, an aminoglycoside was less than 40%. Resistance to Ceftazidime was high. Conclusion: Antimicrobial resistance surveillance is critical to reduce AMR related morbidity and mortality.