Duguma, T., Nuri, A. and Melaku, Y. (2022) Prevalence of Malaria and Associated Risk Factors among the Community of Mizan-Aman Town and Its Catchment Area in Southwest Ethiopia. Journal of Parasitology Research, 2022, Article ID: 3503317.
https://doi.org/10.1155/2022/3503317

has been cited by the following article:

• TITLE: Fixed-Dose Combination (FDC) Formulation of Quinine Sulphate-Doxycycline (Qidox) for Malaria Therapy

  AUTHORS: Widyati Widyati, Timbul Partogi H. Simorangkir, Syahrul Tuba, Taufiq Riyadi, Yuda Prasetya Nugraha, William Ratna Prawira

  KEYWORDS: Malaria, Quinine Sulphate, Doxycycline, FDC

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.1, January 31, 2023

  ABSTRACT: Background: One of the deadliest parasite infections is malaria. A combination of quinine sulphate and doxycycline is another therapeutic option for malaria that is resistant to chloroquine and is anticipated to be able to both combat the issue of anti-malarial medication resistance as well as the compliance to malaria therapy that is still raging in certain locations of Indonesia. Aim: This study will focus on evaluating the possibility of interaction between quinine sulphate and doxycycline followed by formulating the fixed-dose combination of both active pharmaceutical ingredients. Method: The study was designed as a laboratory experiment and applied some examinations. The examination from the organoleptic test of active pharmaceutical ingredients powder, crystallography analysis, and physical analysis of fixed-dose tablet including hardness, friability, and disintegration time testing. Result: The crystallography study reported there was no physical interaction found between quinine sulphate and doxycycline. The formula found excellent tablet printability with a composition of Quinine sulphate and doxycycline (Qidox). Conclusion: quinine sulphate with doxycycline can be combined into one tablet as Fixed-Dose Combination (FDC).