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https://doi.org/10.1017/S1355838299990210

has been cited by the following article:

• TITLE: Oxazolidinones Antibiotics, Chemistry, Applications and Role in COVID-19 Treatment

  AUTHORS: Alaa Saleh Mahdi, Baraa G. Alani, Ismail Taha Ibrahim

  KEYWORDS: Oxazolidinones Antibiotics Linezolid Infection COVID-19

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.14 No.1, January 29, 2023

  ABSTRACT: Oxazolidinones are groups of synthetic antimicrobial agents, which have a novel chemical structure. Their mechanism of antimicrobial mainly bacteriostatic via inhibition of protein synthesis. Oxazolidinones are used in serious cases of bacterial infections. Their spectrum of action against a lot of microbes, which often infect humans vigorously, like penicillin and cephalosporin-resistant Streptococcus pneumonia, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Oxazolidinones chemical structure possesses a ring called oxazolidone, which is characterized by the S configuration of the substituent at C5, the acyl-amino-methyl group connected to C5 and the N-aryl substituent. Some oxazolidinones like linezolid were believed to have a role in COVID-19 treatment. It is also noticed that oxazolidinones have a role in improving clinical status of patients with COVID-19 and in decreasing the risk of mortality caused by co-infections. This review was conducted to discuss the chemistry, mechanism, applications and role of oxazolidinones in the treatment of COVID-19.