TITLE:
Childhood Idiopathic Nephrotic Syndrome: A Single-Center Hospital Study
AUTHORS:
Abdoul Karim Doumbia, Tati Simaga, Adama Dembélé, Mahamadou Salihou Baldé, Hawa G. Diall, Pierre Togo, Aminata Doumbia, Belco Maiga, Karamoko Sacko, Fatoumata Léonie Diakité, Oumou Koné, Oumar Coulibaly, Ibrahim Ahamadou, Mohamed Elmouloud Cissé, Guédiouma Dembelé, Fousseyni Traoré, Hawa Konaré, Amadou Touré, Djènèba Konaté, Lala N’Drainy Sidibé, Leyla Maiga, Abdoul Aziz Diakité, Boubacar Togo
KEYWORDS:
INS, Children, Corticosteroids
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.12 No.5,
November
23,
2022
ABSTRACT: Introduction: Idiopathic nephrotic syndrome (INS) is one of the leading causes of
childhood morbidity worldwide. This study was undertaken to complete the
epidemiological, clinical, therapeutic and evolutionary aspects of NIS in
hospitalized patients. Methodology: We conducted a retrospective study
of patients with childhood NIS who had been admitted to our department from
January 2017 to December 2018. Diagnosis, remission and relapse of idiopathic
NS were defined according to the recommendations of the French Society of
Pediatric Nephrology. We included all patients aged 2 to 14 years presenting a
NIS picture. Results: During the study period, 35 patients with
idiopathic NS had been hospitalized, representing a frequency of 1% of patients
hospitalized in the department. The sex ratio was 2.22. The average age of the
patients was 7.5 ± 3.5 years. Generalized edema was observed in all our
patients. Arterial hypertension (36%) and abdominal pain (24%), hematuria (9%)
were the main associated signs. Malnutrition was present in 66%, urinary tract
infection in 20% and malaria in 24%. Cortico-sensitivity was obtained in 86% of
patients, 14% were cortico-resistant and 11% were cortico-dependent. Relapses
(6%) had been observed among cortico-sensitive patients. The mortality rate was
11%. Conclusion: This study calls for more trials to better elucidate
prognostic indicators and develop better therapeutic approaches adapted to
epidemio-clinical contexts.