TITLE:
Results of the Management of Gastrointestinal Stromal Tumors (GIST): About 6 Cases at the Vichy Hospital Center (France)
AUTHORS:
Omar Sow, Nicolas Sorbane Fetche, Vermare Clarisse, Annabel Bautrand, Alice Anusca, Lionel Perrot
KEYWORDS:
Gastrointestinal Stromal Tumor, Laparoscopic Surgery, Targeted Therapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.7,
July
8,
2022
ABSTRACT: The aim of our study was to analyze the results of surgical management of
gastrointestinal stromal tumors (GIST) at the Vichy Hospital Center. Methodology:
Between 2010 and 2020, the data of 6 patients operated at the Vichy Hospital
Center for GIST were analyzed. The parameters studied were: age, sex,
antecedents, discovery circumstances, imagery, surgical procedure,
anatomopathological data, the follow-up and the morbidity-mortality. Results:
There were 5 men and one woman with an average age of 72.16 years [58 - 80
years]. The average time of evolution was 8 months (0 - 14 months). The
diagnosis was fortuitous in 2 cases. Atypical abdominal pain was the main
symptom in 3 cases. One case was received in a clinical picture of peritoneal
irritation syndrome. Echo-endoscopy with biopsy specimen histology made it
possible to make the diagnosis in 5 cases and the surgical specimen in 1 case.
The fusiform type was the predominant histological form. The stomach was the most
common location. The average size of GISTs was 7.3 × 4 cm with a positive C Kit
in all patients. Neoadjuvant chemotherapy was performed on one
patient. Surgery was curative and was done laparoscopically on 4 patients.
Adjuvant chemotherapy based on Imatinib at a rate of 400 mg/d in 3 patients was
initiated. One patient presented a fistula of the esophagus-jejunal anastomosis
on D6 post operation controlled by a drainage and an antibiotic therapy.
Mortality was zero. During the surgery, all of the patients were followed up with
surgeon, oncologist. Conclusion: GISTs are the most common mesenchymal
tumors of the digestive tract with a preferential gastric location.
Laparoscopic surgery, with advances in molecular biology and the introduction
of targeted therapy has improved the management of these tumors in terms of morbidity and
mortality.