TITLE:
Antioxidant Property of a Dietary Supplement of Moringa oleifera Leaves and Pleurotus ostreatus in Wistar Rats Subjected to Forced Swimming Endurance Test
AUTHORS:
Fatou Corka Kane, Djimadoum Kimassoum, Simo Fredy Brice, Moundipa F. Paul, Wilfred F. Mbacham
KEYWORDS:
Moringa oleifera, Pleurotus ostreatus, Dietary Supplement, Antioxidant, Oxidative Stress
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.13 No.5,
May
31,
2022
ABSTRACT: The
antioxidant property of Moringa oleifera leaves and Pleurotus ostreatus on swimming performance and related biochemical
parameters were investigated in thirty adult male and female wistar rats. Purpose: The aim of the present study was to evaluate the antioxidant property
of M. oleifera and P. ostreatus mixture in specific proportions
in wistar rats. Material and Methods: The mushroom species and M.
oleifera leaves were cultivated at the biotechnology laboratory of
the University Cheikh Anta Diop de Dakar, Senegal. Oxidative
stress in rats was induced by swimming. The dietary supplement was composed of a mixture of powders of Moringa oleifera and Pleurotus ostreatus in 2:1
ratio. Three groups received different
doses of dietary supplements 500 mg/kg, 1000 mg/kg, and 1500 mg/kg, with one group being the stressed and the other the control group. Parameters in serum such as serum glutamyl oxaloacetate
transaminase, serum glutamyl pyruvate transaminase, albumin, Testosterone,
creatinine, and,
oxidative stress parameters (catalase, reduced glutathione, and
malondialdehyde) were measured. Results: Results showed that the dietary
supplement has an effect on oxidative stress because it increases the activity
of catalase and the level of cellular glutathione in rats. The 500 mg/kg dose
would be the most appropriate dose for stressful conditions. The 1000 mg/kg
dose would be the most appropriate dose for liver damage. Conclusion: This study shows that
the antioxidant properties of M. oleifera leaves and Pleurotus ostreatus are demonstrated by
their ability to improve body energy stores and tissue antioxidant capacity. The dietary supplement of M. oleifera leaves and P. ostreatus powders mixture could be good in stressful conditions.