TITLE:
Multi-Metastatic Hepatoid Adenocarcinoma of the Lung: Report of Case
AUTHORS:
Toky Rakotoarivo, Christian Tomboravo, Malala Razakanaivo, Narindra Rajaonarison Ny Ony, Clairette Raharisolo, Florine Rafaramino
KEYWORDS:
Hepatoid Adenocarcinoma, Lung, Chemothérapy, Metastasis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.5,
May
31,
2022
ABSTRACT: Hepatoid adenocarcinoma of the lung is a rare tumor with a poor prognosis.
There are no specific treatment-recommendations for this cancer. We report a
59-year-old man, a former smoker, with this condition. He presented with a cough and
computed tomography revealed a pulmonary nodule (50 × 47 × 48 mm) with
a right pleural effusion, together with a cerebral right temporal-lobe lesion
and a right adrenal lesion. The serum alpha-fetoprotein value was normal.
Histological examination via bronchoscopic biopsy revealed an adenocarcinoma.
Positive CK7, AE1/AE2, and TTF1 with granular cytoplasmic staining on immunohistochemical study
confirmed the diagnosis of hepatoid adenocarcinoma of the lung, stage IV-B. The
patient had received chemotherapies (carboplatin-pemetrexed, gemcitabine) and
cerebral radiotherapy, but he died at eight months of the treatment as a result
of tumor progression.