El-Helby, A., Sakr, H.M., Ayyad R.R. and Mahdi, H. (2020) Design, Synthesis, Molecular Modeling, in Vivo Studies and Anticancer Activity Evaluation of New Phthalazine Derivatives as Potential DNA Intercalators and Topoisomerase II Inhibitors. Bioorganic Chemistry, 103, Article ID: 104233.
https://doi.org/10.1016/j.bioorg.2020.104233

has been cited by the following article:

• TITLE: Design and Synthesis of Some New Oxadiazole Derivatives as Anticancer Agents

  AUTHORS: Mo’men Salem, Rezk Ayyad, Helmy Sakr

  KEYWORDS: Phenyl Hydrazine, Oxadiazole, Aromatic Aldehydes, Acetic Anhydride, Benzylidene Synthesis, Cytotoxic Assay, Anticancer, HepG2 and MCF-7

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.12 No.2, May 10, 2022

  ABSTRACT: In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4-dimethyl-4-phenyloxadiazole. This product was reacted with a series of aromatic aldehydes, to obtain a series of oxadiazole derivatives. These derivatives were characterized by TLC, melting points, infrared red, proton nuclear magnetic resonance, carbon thirteen nuclear magnetic resonance and mass spectroscopy. Finally, these synthetized derivatives were tested for antiproliferative activity by two different cell lines. MCF-7 (Breast cancer cell line) and HepG2 (Liver cancer cell line) were used to assess the antiproliferative activity of the prepared compounds.