TITLE:
The Effect of Gum Acacia on Post-Prandial Glucose and Insulin Levels in Healthy Subjects
AUTHORS:
Udo Bongartz, Constantin Erlenbeck, Irene Wohlfahrt
KEYWORDS:
Acacia Gum, Post-Prandial Glucose, Post-Prandial Insulin, Glycemic Response Control
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.13 No.4,
April
26,
2022
ABSTRACT: This
double-blind, controlled, randomized, three-way cross-over study evaluates the
effect of 40 g (D1 group) and 20 g (D2 group) of acacia gum (AG) versus no
treatment (NT group) on post-prandial glucose (PPG) levels in normal-weight and
overweight subjects. Additionally, post-prandial insulin (PPI) levels as well
as the safety and tolerability of gum acacia were assessed. 35 healthy subjects
aged 25 - 60 years, body mass index 18.5 kg/m2 - 29.9 kg/m2,
received one treatment of 20 g, 40 g, or 0 g of AG each. Glucose and insulin
values were determined at -15 min and prior to the intake (time “0”) as well as 15, 30, 45, 60, 90
120, and 180 min after the “0 min” blood draw. The mean PPG levels were lower
(34% in D1 group, p = 0.003; 35% in D2 group, p = 0.005) than in the NT group.
PPI concentration was statistically significantly lower at all time points
except baseline in both treatment groups compared to NT groups. Global benefit
and tolerability were rated as “very good” or “good” by 100% of subjects in the
treatment groups. This study provides robust evidence of the significant benefits of AG consumption on PPG and PPI levels in healthy
subjects. Moreover, very good tolerability was demonstrated.