TITLE:
Protective Effects of Vitamin E on Albendazole Adverse Effects
AUTHORS:
Catherin V. Adiang, Sawsan M. El-Sheik, Gamal El-Din A. Shams Abdel Aleem, Fouad AbdelAleem
KEYWORDS:
Albendazole, Vitamin E, Antioxidant Enzymes
JOURNAL NAME:
Open Journal of Veterinary Medicine,
Vol.11 No.10,
October
30,
2021
ABSTRACT: The present study was conducted to determine the effect of albendazole
alone or in combination with vitamin E on
antioxidant activity and histopathological, changes on the liver and kidney.
Following oral administration of albendazole of 0.25 mg/kg
body weight and Vitamin E of 0.01 mg/kg
body weight used for 21 successive days to
broiler chicken, the experiment was done on fifteen broiler chickens divided into three groups: group one was non-treated, group two was treated with albendazole of 0.25 mg/kg
body weight and group three was treated in combination with vitamin E of 0.01 mg/kg
body weight. The blood sample and tissue
were taken at the end of experiment 12 hrs
after the last dose. The
experimental result revealed that the significant decrease of liver enzymes
caused by albendazole like serum Alanine Aminotransferase (ALP), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALT), when compared with the control group, the experimental result significant decrease in kidney parameters like urea creatinine level caused by
albendazole and finally there was a significant increase in antioxidant enzymes activity
like CAT, SOP, GPX and a significant decrease in MDA.
Histopathology results in liver-treated animals with albendazole in combination with vitamin E showed dilated, congested Portal Blood Vessels (PBV, arrow), mild to moderate Biliary
Proliferation (BP, arrow), portal
Round Cells Aggregation (RCA, arrow), and focal Hepatocellular Degeneration
(HCD, arrow). Histopathology results of kidney-treated animals with al- bendazole in combination with vitamin E showing a
mild Per Tubular Edema (PTE arrow), focal Tubular Degeneration (TD arrow), Tubular Regeneration (TR, arrow), glomerular lobulation and atrophy (GL arrow), and beside
interstitial cells aggregation (RCA arrow), H & EX 200. Therefore, vitamin E should
be taken by albendazole to
decrease its effect.