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https://doi.org/10.1021/jf000156i

has been cited by the following article:

• TITLE: Flavonoids Reduce Lipid Peroxides and Increase Glutathione Levels in Pooled Human Liver Microsomes (HLMs)

  AUTHORS: William Yaw Boadi, Camille Stevenson, Dontrez Johnson, Mohamed Adel Mohamed

  KEYWORDS: Flavonoids, Glutathione (GSH), Human Liver Microsomes (HLMs), Lipid Peroxidation, Oxidative Stress

  JOURNAL NAME: Advances in Biological Chemistry, Vol.11 No.6, December 15, 2021

  ABSTRACT: The effects of each of the flavonoids; genistein (G), quercetin (Q) and kaempferol (K) at several doses on lipid peroxides (LP) and reduced glutathione (GSH) in pooled human liver microsomes (HLMs) were investigated following the oxidative damage for 4, 6, 18 and 24 hr. HLMs (1 mg/ml) were exposed to each of the above flavonoids at 0, 5, 10, 15, 20 or 25 μM and incubated for the respective times as previously stated. Our hypothesis was that HLMs exposed to the flavonoids for the respective exposure times can decrease LP and increase GSH in HLMs to better cope with the oxidative stress. The results of our studies indicate that each of the flavonoids significantly (p levels observed for Q for the 24-hr. incubation. The findings suggest that the flavonoids modulate oxidative stress in HLMs by decreasing LP and such decreases in LPs may be due to the increasing and or the replenished levels of GSH in the said cells to better cope with the oxidative stress.