Hornung, M., Bertog, S.C., Franke, J., Id, D., Taaffe, M., Wunderlich, N., et al. (2013) Long-Term Results of a Randomized Trial Comparing Three Different Devices for Percutaneous Closure of a Patent Foramen Ovale. European Heart Journal, 34, 3362-3369.
https://doi.org/10.1093/eurheartj/eht283

has been cited by the following article:

• TITLE: Ischemic Stroke Due to Paradoxical Embolism in a Patient with Patent Foramen Ovale, Bilateral Distal Deep Vein Thrombosis and Platypnea-Orthodeoxia Syndrome: A Case Report

  AUTHORS: Viola Tallarico, Rossella Loiacono, Silvia Gianstefani, Giovanni Maria Puddu, Paola Forti, Marco Zoli

  KEYWORDS: Patent Foramen Ovale, Cryptogenic Stroke, Paradoxical Embolism, Platypnea-Orthodeoxia Syndrome

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.11 No.10, October 28, 2021

  ABSTRACT: Patent foramen ovale (PFO) is a common congenital cardiac defect. It is usuallyasymptomatic, but it can be associated with relevant clinical manifestations such as cryptogenic stroke and platypnea-orthodeoxia syndrome. We present the case of a patient with hemodynamically significant carotid artery stenosis who underwent endarterectomy for a transient ischemic attack (TIA). After surgery, the patient presented an ischemic stroke due to M2 occlusion treated with mechanical thrombectomy. During hospitalization,a distal bilateral deep vein thrombosis was found. The patient developed respiratory failure due to a massive right-to-left shunt through a large PFO (platypnea-orthodeoxia syndrome).These findings are consistent with the hypothesis that the TIA and the subsequential ischemic stroke were related to paradoxical embolism rather than atherothromboembolism. The aim of our case report is to raise awareness of the possible complications of such a common finding as PFO.