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https://doi.org/10.1002/(SICI)1097-0142(19970601)79:11<2229::AID-CNCR22>3.0.CO;2-X

has been cited by the following article:

• TITLE: Clear Cell Carcinoma of the Uterine Cervix Arising from an Interstitial Cyst Complicated with Endometriosis: A Case Report

  AUTHORS: Kana Akagi, Takako Tobiume, Ayaka Kawamichi, Yuichiro Koshida, Yusuke Fujikami, Eri Ogura, Kenji Ban, Hisanori Matsumoto, Atsuhiko Okagaki, Keiji Tatsumi

  KEYWORDS: Cancer, Clear Cell Carcinoma, Endometriosis, Uterine Cervix

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.11 No.3, March 18, 2021

  ABSTRACT: Clear cell carcinoma (CCC) of the uterine cervix is rare, and its etiology is unclear, except for reports of prenatal diethylstilbestrol (DES) exposure. In this case report of a 78-year-old postmenopausal Japanese woman with pelvic endometriosis, cervical CCC presented as a deep interstitial tumor, strongly suggesting the patient suffered from cervical endometriosis for a long time. A cystic lesion without solid components was detected in the uterine cervix. Although the patient had regular gynecological examinations every 6 months, she presented 5 years later with a complaint of watery vaginal discharge. Ultrasonography and magnetic resonance imaging (MRI) detected a uterine cervical cystic mass with a solid component. Although no malignancy was confirmed preoperatively, surgery was performed under a high suspicion of cervical cancer. Intraoperative pathology revealed CCC in a solid tumor, so debulking surgery, including lymphadenectomy, was done. Endometrial tissue was found adjacent to the tumor, strongly suggesting the tumor arose from cervical endometriosis. Because endometriosis in ectopic sites carries a risk of carcinogenesis, as is the case in ovarian endometriosis, it may be recommended that a cervical cystic lesion with pelvic endometriosis should be followed up regularly for the early detection of uterine cancer.