Dey, S., Sarkar, S., Zangrando, E., Evans, H.S., Sutter, J.-P. and Chattopadhyay, P. (2011) 2-Benzoylpyridine and Copper(II) Ion in Basic Medium: Hydroxide Nucleophilic Addition Stabilized by Metal Complexation, Reactivity, Crystal Structure, DNA, Binding Study and Magnetic Behavior. Inorganica Chimica Acta, 367, 1-8.
https://doi.org/10.1016/j.ica.2010.11.012

has been cited by the following article:

• TITLE: Synthesis, Characterization and Biological Activities of Binuclear Metal Complexes of 2-Benzoylpyridine and Phenyl(Pyridin-2-yl) Methanediol Derived from 1-Phenyl-1-(Pyridin-2-yl)-N-(Pyrimidin-2-yl) Methanimine Dihydrate Schiff Base

  AUTHORS: Francis A. Ngounoue Kamga, Evans Ngandung Mainsah, Maurice Kuate, Peter T. Ndifon

  KEYWORDS: Binuclear Complexes, Schiff Base, 2-Benzoylpyridine, Crystal Structure, Antimicrobial Activity, Antioxidant Activity

  JOURNAL NAME: Open Journal of Inorganic Chemistry, Vol.11 No.1, January 29, 2021

  ABSTRACT: The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L1) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using 13C-NMR, 1H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L1) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L1 to give binuclear metal complexes of 2-benzoylpyridine (L2) and phenyl(pyridin-2-yl)methanediol (L3) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L1) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L2) and phenyl(pyridin-2-yl)methanediol (L3) from the hydrolysis of L1. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). In vitro antibacterial and antifungal activity against three bacterial strains (Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus) and three fungal stains (Candida albicans, Candida glabrata and Candida parapsilosis) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.