TITLE:
Hazarders of Smoking and Helicobacter pylori Infection on Gastric Mucosa among Egyptian Patients with Dyspepsia
AUTHORS:
Rasha I. Salama, Mahmoud W. Emara, Shimaa M. El Sharawy
KEYWORDS:
Dyspepsia, Helicobacter pylori, Smoking, Egypt
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.11 No.1,
January
26,
2021
ABSTRACT: Background: Smoking is hazardous to almost any organ in the body and has a harmful
effect on the gastric mucosa. Objective: The main goal of this study was
to evaluate the synergistic effect of smoking and H. pylori infection on gastric
mucosal among dyspeptic Egyptian patients. Patients and Methods: A
cross-sectional study was conducted among 240 consecutive patients with dyspepsia
who underwent upper endoscopy and histopathological examination of gastric
biopsies at Zagazig and Tanta University Hospital with H. pylori-positivity assessment
by stool antigen and rapid urease test. Results: There were 60 smoker
patients and 180 non-smoker patients. Erosive gastritis was more prevalent in
smoker patients than non-smoker patients (46.7% versus 15.6%, p = 0.00). In H. pylori-positive patients (36.7% of all patients),
smokers were more prevalent than non-smokers in the development of intestinal metaplasia (20% versus 0%, p = 0.003), erosive gastritis (80% versus 30%, p = 0.00),
glandular atrophy (20% versus 0%, p = 0.003)
and reactive gastropathy (20% versus 0%, p = 0.003). Conclusions: This study revealed that smoking may increase the prevalence of having gastric intestinal
metaplasia, erosive gastritis, glandular
atrophy and reactive gastropathy in H. pylori-positive Egyptian patients.