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https://doi.org/10.1016/j.ijsu.2018.09.010

has been cited by the following article:

• TITLE: Palonosetron versus Ondansetron as Prophylaxis against Postoperative Nausea and Vomiting (PONV) after Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial

  AUTHORS: Ayman A. Elrashidy, Mohamed Elsherif, Wahiba Elhag, Omar Abdelaziem, Sherif Abdelaziem, Reda Sobhi Abdel-Rahman

  KEYWORDS: Palonosetron, Ondansetron, Postoperative Nausea and Vomiting, PONV, Retching Laparoscopic Sleeve Gastrectomy, LSG, Bariatric Surgery

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.10 No.10, October 30, 2020

  ABSTRACT: Introduction:Postoperative nausea and vomiting (PONV) are prevalent symptoms after laparoscopic surgeries with an incidence rate of (54% -79%) in bariatric procedures. Despite its popularity, limited studies assessed the effect of antiemetics for PONV prophylaxis after laparoscopic sleeve gastrectomy (LSG). The aim of this trail is to compare the effectiveness of a single pre-induction intravenous dose of Palonosetron versus Ondansetron for prophylaxis of PONV, 24 hours after LSG. Subjects and Methods:This prospective randomized controlled double-blind parallel-group study wasconducted from May till December 2019. Recruited patients were consented and randomized using a closed envelop method into two groups with fifty patients each.The total number of nausea and vomiting attacks in the 24 hours postoperatively was considered as a primary end point. The secondary end points were the frequency of nausea, retching and vomiting attacks in the 24 hours post-surgery.The severity of nausea was evaluated using a 10 cm visual analogue scale (VAS).Results:This RCT included 100 patients divided into 2 groups of 50 patients each. Patients received either 75mcg Palonosetron (Group I) or Ondansetron 4 mg (group II).Group I had statistically significant fewer episodes of nausea, retching and vomiting in the first 4 hours (P=0.022)and from 4 to 12hours(P=0.024)but not after 12 hours postLSG. Total episodes of nausea, retching and vomiting in 24 hours postoperative were significantly less in group I(P=0.021).Conclusion:A single dose of intravenous 75mcg Palonosetron is superior to Ondansetron 4 mg in preventing PONV for patients after LSG.