TITLE:
ADAMTS-8 Activity in Synovial Cells in Patients with Rheumatoid Arthritis
AUTHORS:
Murat Baloğlu, Engin Deveci, Şenay Deveci
KEYWORDS:
Romatoid Artrit, Sinovial Fluid, ADAMTS-8
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.10 No.3,
June
16,
2020
ABSTRACT: Rheumatoid arthritis (RA), chronic, autoimmune causing joint stiffness,
pain, fatigue and functional disorders is a disease. The aim
of this study is to investigate the presence
of ADAMTS-8 expression in cells in synovial fluid in rheumatoid arthritis
patients. Patients with active RA were aspirated with arthro synthesis from the knee joint. Blood samples were taken from the
patients at the same time, plasma samples were separated. Patients with
sinovial fluid treated between 2019-2020 year in the Gazi Yaşargil
Hospital Physical Therapy and Rehabilitation Clinic were involved in the study
that was consulted with knee pain and difficulty in performing their daily
activities. Informed consent form was obtained from all of the patients (10 RA
and 10 patients). CRP, RF and ESH results were statistically evaluated in patients with
Control and Rheumatoid arthritis. CRP, RF
and ESH results were statistically evaluated in patients with Control and
Rheumatoid arthritis. In patient samples with Rheumatoid arthritis, degeneration in synovial
cells was observed in some nuclei in the form of pycnosis and apoptotic. ADAMTS-8
expression in the form of aggregates in synovial cells was found to be
positive. It was observed that rheumatoid arthritis increased apoptotic change
in synovial cells. ADAMTS8 in synovial cells in rheumatoid arthritis cases may cause a
significant increase in apoptosis levels by
suppressing some signal pathways, and predicts that apoptosis induction may
play a role in the inhibition of ADAMTS8-mediated synovial cell proliferation.