TITLE:
To Explore the Potential Mechanism of Yiqing Capsule in the Treatment of COVID-19 Based on Network Pharmacology
AUTHORS:
Ying Wang, Jingyi Zhao, Yinhui Yao, Song Jiang, Xinhong Zhao, Junhui Hu
KEYWORDS:
Yiqing Capsule, Network Pharmacology, COVID-19
JOURNAL NAME:
Chinese Medicine,
Vol.11 No.2,
June
8,
2020
ABSTRACT: Objective: To
select the ingredients and targets of Yiqing capsule in treating COVID-19 based
on network pharmacology, then to explore the potential mechanism of Yiqing
capsule in treating COVID-19. Methods: We screened
the ingredients and targets of Yiqing capsule on Traditional Chinese Medicine
Systems Pharmacology Database and Analysis Platform (TCMSP), and target genes
for COVID-19 in GeneCards database, constructed drug-ingredient-target network through software Cytoscape 3.7.2, and constructed protein protein interaction network (PPI) network through
STRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia
of Genes and Genomes (KEGG) analysis of key gene targets of Yiqing capsule are used to treat
COVID-19 through software R5.3.2. Results: We got 42 ingredients, 42 potential therapeutic targets, 1643 GO items
and 970 pathways in our study. The main pathway including IL-17 signaling
pathway, Chagas disease (American trypanosomiasis), Influenza A, and TNF
signaling pathway. Conclusion: Yiqing capsule plays a role in treating COVID-19 through multiple
ingredients, multiple targets and multiple pathways.