TITLE:
PLK1 Is Implicated in the Poor Prognosis of Hepatocellular Carcinoma
AUTHORS:
Ruifeng Xun, Hougen Lu, Xianwang Wang
KEYWORDS:
PLK1, HCC, TCGA, Biomarker, Cancer Therapy
JOURNAL NAME:
Yangtze Medicine,
Vol.4 No.3,
June
30,
2020
ABSTRACT: We aimed to identify if PLK1 could be used as a new diagnostic and therapeutic biomarker in hepatocellular carcinoma (HCC) patient. Expression of PLK1 in HCC was analyzed by using GEPIA (Gene Expression Profiling Interactive Analysis) and UALCAN databases. GEPIA and CBioPortal tools were applied to determine patients’ survival and PLK1 mutations, respectively. PPI (Protein-Protein Interaction) networks were further built by STRING (Search Tool for the Retrieval of Interacting Genes) and Metascape Web portals. The data demonstrated that the expression of PLK1 in HCC was significantly enhanced when compared to normal liver tissues (P