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https://doi.org/10.1021/jm0605740

has been cited by the following article:

• TITLE: Synthetic of Some New Fluorine Compounds Bearing 1,2,4-Triazine Moieties and the Related Hetero-Polycyclic Nitrogen Systems as Pharmacological Probes-Overview

  AUTHORS: Fatimah A. Alotaibi, Dina A. Bakhotmah

  KEYWORDS: Design, Synthesis, Fluorinated 1, 2, 4-Triazino/1, 2, 4-Triazinone, Medicinal Properties

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.10 No.1, March 18, 2020

  ABSTRACT: This overview summarizes recent advanced literature surveys on the synthesis of fluorine substituted 1,2,4-triazine containing various functional groups and/or the related hetero-polycyclic nitrogen systems have been reported. In addition, physical, chemical, and medicinal properties have been evaluated. The presence of fluorinated atoms often improves these properties with an increasing electronegativity. It, also, enhances the stability of formed carbanion and it improves the hydrophobic effects which have good biological activities.